Yılmaz Samet, Çiğdem Burhanettin, Gökçe Şeyda Figül, Ceyhan-Doğan Sevil, Balaban Hatice
1 Department of Neurology, Cumhuriyet University School of Medicine, Sivas, Turkey.
2 Department of Physical Medicine and Rehabilitation Cumhuriyet University School of Medicine, Sivas, Turkey.
J Int Med Res. 2017 Aug;45(4):1340-1346. doi: 10.1177/0300060517704789. Epub 2017 Jun 12.
Restless legs syndrome (RLS) is a common sensory motor disorder. RLS an urge to move the extremities that may be accompanied by dysesthesias, and significantly affects quality of life of affected patients. The frequency of RLS is higher in different systemic inflammatory diseases. Familial Mediterranean fever (FMF) is an inherited inflammatory disease characterized by attacks of polyserositis, arthritis, and fever. The prevalence of RLS in patients with FMF is unknown. This study aimed to evaluate the prevalence rate of RLS in a sample of patients with FMF and compare this prevalence with that of a matched normal population.
A total of 60 patients with FMF and 60 healthy controls were studied. All participants underwent a neurological examination. Diagnostic criteria as proposed by the International Restless Legs Syndrome Study Group (IRLSSG) were used to define RLS. The IRLSSG rating scale for the severity of RLS was applied to determine the severity of symptoms.
The prevalence of RLS was not significantly different between patients and controls. Although the mean International Restless Legs Syndrome Rating Scale (IRLSRS) scores tended to be higher in patients compared with controls, this difference was not significant. When each item of the severity scale was compared between the two groups, significantly higher scores were found in some items of the IRLSRS in patients with FMF compared with controls.
According to this result, RLS symptoms in patients with FMF were more frequent and lasted longer than those in controls.
不宁腿综合征（RLS）是一种常见的感觉运动障碍。RLS表现为肢体有活动的冲动，可能伴有感觉异常，严重影响患者的生活质量。在不同的全身性炎症性疾病中，RLS的发生率较高。家族性地中海热（FMF）是一种遗传性炎症性疾病，其特征为多发性浆膜炎、关节炎和发热发作。FMF患者中RLS的患病率尚不清楚。本研究旨在评估FMF患者样本中RLS的患病率，并将该患病率与匹配的正常人群进行比较。
共研究了60例FMF患者和60例健康对照者。所有参与者均接受了神经系统检查。采用国际不宁腿综合征研究组（IRLSSG）提出的诊断标准来定义RLS。应用IRLSSG的RLS严重程度评分量表来确定症状的严重程度。
患者和对照组之间RLS的患病率无显著差异。虽然患者的国际不宁腿综合征评分量表（IRLSRS）平均得分往往高于对照组，但这种差异并不显著。当比较两组严重程度量表的各项时，发现FMF患者的IRLSRS某些项目得分显著高于对照组。
根据这一结果，FMF患者的RLS症状比对照组更频繁，持续时间更长。
