Huang Huimei, Ruan Qinyun, Lin Meiyan, Yan Lei, Huang Chunyan, Fu Liyun
Department of Ultrasound, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
Cardiovasc Ultrasound. 2017 Jun 12;15(1):14. doi: 10.1186/s12947-017-0106-7.
This study is aimed at investigating myocardial multi-directional systolic deformation in hypertensive with different left ventricular ejection fraction (LVEF), and exploring its contribution to LVEF.
One hundred and twenty-three patients with primary hypertension (HT) were divided into group A (LVEF ≥ 55%), group B (45% ≤ LVEF < 50%, or 50% ≤ LVEF < 55% + LVEDVI ≥ 97 ml/m), and group C (LVEF < 45%). Two-dimensional strain echocardiography (2DSE) including LV longitudinal strain (SL), radial strain (SR) and circumferential strain (SC) were measured.
SL decreased gradually from group A, B to C (all p < 0.05) while SR and SC were reduced only in group B and C (all p < 0.05). All strain measurements correlated to LVEF, with the strongest correlation in SC (r = -0.82, p < 0.01) and the second in SL (r = -0.76). The diastolic E/e increased from group A, B to C.
Left ventricular multi-directional deformation correlated well to LVEF in hypertension and particularly SC, indicating that it was SC, not SL or SR, that makes the prominent contribution to left ventricular pump function.
本研究旨在调查不同左心室射血分数（LVEF）的高血压患者的心肌多方向收缩变形，并探讨其对LVEF的影响。
123例原发性高血压（HT）患者分为A组（LVEF≥55%）、B组（45%≤LVEF<50%，或50%≤LVEF<55%+左心室舒张末期容积指数（LVEDVI）≥97 ml/m）和C组（LVEF<45%）。采用二维应变超声心动图（2DSE）测量左心室纵向应变（SL）、径向应变（SR）和圆周应变（SC）。
SL从A组、B组到C组逐渐降低（均p<0.05），而SR和SC仅在B组和C组降低（均p<0.05）。所有应变测量值均与LVEF相关，其中SC相关性最强（r=-0.82，p<0.01），SL次之（r=-0.76）。舒张期E/e从A组、B组到C组升高。
高血压患者左心室多方向变形与LVEF密切相关，尤其是SC，表明对左心室泵功能起主要作用的是SC，而非SL或SR。
