N-乙酰天门冬氨酰谷氨酸：作为外侧嗅束神经递质的可能作用。
N-Acetylaspartylglutamate: possible role as the neurotransmitter of the lateral olfactory tract.
作者信息
Ffrench-Mullen J M, Koller K, Zaczek R, Coyle J T, Hori N, Carpenter D O
出版信息
Proc Natl Acad Sci U S A. 1985 Jun;82(11):3897-900. doi: 10.1073/pnas.82.11.3897.
Abstract
N-Acetylaspartylglutamate, an endogenous brain peptide that binds with high affinity to a subpopulation of glutamate-binding sites in rat brain, is excitatory on rat piriform cortex pyramidal cells studied in a perfused brain slice. Both the monosynaptic excitation of the pyramidal cells elicited by stimulation of the lateral olfactory tract and the response to N-acetylaspartylglutamate were blocked by DL-2-amino-4-phosphonobutyrate but not by other excitatory amino acid antagonists. Responses to glutamate and aspartate, previously considered to be candidates as the lateral olfactory tract transmitter, were unaffected by 2-amino-4-phosphonobutyrate. Three days after unilateral bulbectomy there was a significant decrease in concentrations of N-acetylaspartylglutamate as well as aspartate, N-acetylaspartate, and gamma-aminobutyrate in the pyriform cortex of the side from which the olfactory bulb had been removed. These results are consistent with the possibility that N-acetylaspartylglutamate is the endogenous transmitter of the lateral olfactory tract.
摘要
N-乙酰天门冬氨酰谷氨酸是一种内源性脑肽，它能与大鼠脑中谷氨酸结合位点的一个亚群高亲和力结合，对灌注脑片中研究的大鼠梨状皮质锥体细胞具有兴奋性。刺激外侧嗅束引起的锥体细胞单突触兴奋以及对N-乙酰天门冬氨酰谷氨酸的反应均被DL-2-氨基-4-膦酰丁酸阻断，但不被其他兴奋性氨基酸拮抗剂阻断。对谷氨酸和天冬氨酸的反应（以前被认为是外侧嗅束递质的候选物）不受2-氨基-4-膦酰丁酸的影响。单侧嗅球切除术后三天，切除嗅球一侧的梨状皮质中N-乙酰天门冬氨酰谷氨酸以及天冬氨酸、N-乙酰天门冬氨酸和γ-氨基丁酸的浓度显著降低。这些结果与N-乙酰天门冬氨酰谷氨酸是外侧嗅束内源性递质的可能性一致。
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Proc Natl Acad Sci U S A. 1985 Jun;82(11):3897-900. doi: 10.1073/pnas.82.11.3897.
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