帕金森病的嗅觉阈值
Olfactory threshold in Parkinson's disease.
作者信息
Quinn N P, Rossor M N, Marsden C D
出版信息
J Neurol Neurosurg Psychiatry. 1987 Jan;50(1):88-9. doi: 10.1136/jnnp.50.1.88.
Abstract
Olfactory threshold to differing concentrations of amyl acetate was determined in 78 subjects with idiopathic Parkinson's disease and 40 age-matched controls. Impaired olfactory threshold (previously reported by others) was confirmed in Parkinsonian subjects compared with controls. There was no significant correlation between olfactory threshold and age, sex, duration of disease, or current therapy with levodopa or anticholinergic drugs. In a sub-group of 14 levodopa-treated patients with severe "on-off" fluctuations, no change in olfactory threshold between the two states was demonstrable. Olfactory impairment in Parkinson's disease may involve mechanisms that are not influenced by pharmacologic manipulation of dopaminergic or cholinergic status.
摘要
对78名特发性帕金森病患者和40名年龄匹配的对照者测定了对不同浓度乙酸戊酯的嗅觉阈值。与对照组相比，帕金森病患者存在嗅觉阈值受损（此前已有其他人报道）。嗅觉阈值与年龄、性别、病程或目前使用左旋多巴或抗胆碱能药物治疗之间无显著相关性。在14名接受左旋多巴治疗且有严重“开-关”波动的患者亚组中，未发现两种状态下嗅觉阈值有变化。帕金森病的嗅觉损害可能涉及不受多巴胺能或胆碱能状态药物操纵影响的机制。
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