N-乙酰天门冬氨酸在哺乳动物大脑中的作用研究。
Studies on the role of N-acetylaspartic acid in mammalian brain.
作者信息
JACOBSON K B
出版信息
J Gen Physiol. 1959 Nov;43(2):323-33. doi: 10.1085/jgp.43.2.323.
Abstract
N-Acetylaspartic acid (NAA) occurs at relatively high concentrations exclusively in the mammalian and avian brain and undergoes rapid rise in level soon after birth (Tallan, 1957). The amount of NAA in brains of mentally abnormal human beings and of young human beings was measured. The route by which NAA is synthesized was shown to involve a direct acetylation of aspartic acid. The degradative activity of the brain toward NAA is slight. Some experiments indicate that NAA in the brain is a physiologically and metabolically active compound.
摘要
N-乙酰天门冬氨酸（NAA）仅在哺乳动物和鸟类大脑中以相对较高的浓度存在，出生后不久其水平会迅速上升（塔兰，1957年）。对精神异常的人类和年轻人大脑中的NAA含量进行了测量。结果表明，NAA的合成途径涉及天门冬氨酸的直接乙酰化。大脑对NAA的降解活性很轻微。一些实验表明，大脑中的NAA是一种具有生理和代谢活性的化合物。
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