Stinus L, Winnock M, Kelley A E
Psychopharmacology (Berl). 1985;85(3):323-8. doi: 10.1007/BF00428196.
In the present study the functional relationship between enkephalinergic and dopaminergic neurones at the level of the nucleus accumbens was investigated. The study consisted of two experiments in which dopaminergic (DA) transmission was chronically inhibited, and the behavioural locomotor response to intra-accumbens opiate injections analysed. First, specific 6-OHDA lesion of the DA-A10 neurones (either in nucleus accumbens or ventral tegmental area) was found markedly to increase the behavioural excitatory effects induced by nucleus accumbens injection of opioid peptides or morphine. Specific lesion of the central noradrenergic neurones had no such effect. Second, chronic pharmacological blockade of DA activity either with reserpine or a neuroleptic (pipothiazine palmitate) similarly induced a strong enhancement of the behavioral response to intra-accumbens opiate injection. The results are discussed in terms of novel mechanisms underlying denervation supersensitivity, and may have important implications for the relation between dopamine dysfunction in mental illness and opiate addiction.
在本研究中，对伏隔核水平上脑啡肽能神经元和多巴胺能神经元之间的功能关系进行了研究。该研究包括两个实验，其中多巴胺能（DA）传递被长期抑制，并分析了对伏隔核内注射阿片类药物的行为运动反应。首先，发现对DA - A10神经元（伏隔核或腹侧被盖区）进行特异性6 - 羟基多巴胺损伤可显著增强伏隔核注射阿片肽或吗啡所诱导的行为兴奋效应。中枢去甲肾上腺素能神经元的特异性损伤则无此效应。其次，用利血平或抗精神病药物（棕榈酸哌泊噻嗪）对DA活性进行慢性药理阻断同样会强烈增强对伏隔核内注射阿片类药物的行为反应。从去神经超敏反应的新机制角度对结果进行了讨论，这些结果可能对精神疾病中多巴胺功能障碍与阿片类药物成瘾之间的关系具有重要意义。
