帕金森病对人脑中的甲硫氨酸脑啡肽和亮氨酸脑啡肽的影响不同。
Parkinson's disease affects differently Met5- and Leu5-enkephalin in the human brain.
作者信息
Taquet H, Javoy-Agid F, Hamon M, Legrand J C, Agid Y, Cesselin F
出版信息
Brain Res. 1983 Dec 5;280(2):379-82. doi: 10.1016/0006-8993(83)90071-9.
When measured in post-mortem human control brains, the ratio of Met5-enkephalin levels to those of Leu5-enkephalin varied from 1 to 13 in the 11 areas examined. In parkinsonian brains a significant reduction in the levels of both peptides was found in the pallidum and putamen whereas only Met5-enkephalin levels were decreased in the substantia nigra and ventral tegmental area. Therefore, Met5-enkephalin and Leu5-enkephalin may be located (at least partly) in different neuronal populations in the human brain.
在对人类死后的对照大脑进行检测时，在所检测的11个区域中，甲硫氨酸脑啡肽水平与亮氨酸脑啡肽水平的比值在1到13之间变化。在帕金森病患者的大脑中，苍白球和壳核中这两种肽的水平均显著降低，而黑质和腹侧被盖区仅甲硫氨酸脑啡肽水平降低。因此，甲硫氨酸脑啡肽和亮氨酸脑啡肽可能（至少部分）位于人类大脑的不同神经元群体中。
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