抗生素介导的肠出血性大肠杆菌 O104:H4 和 O157:H7 外膜囊泡的调控。
Antibiotic-Mediated Modulations of Outer Membrane Vesicles in Enterohemorrhagic Escherichia coli O104:H4 and O157:H7.
机构信息
Institute for Hygiene, University of Münster, Münster, Germany.
Interdisciplinary Center for Clinical Research (IZKF), University of Münster, Münster, Germany.
出版信息
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.00937-17. Print 2017 Sep.
Abstract
Ciprofloxacin, meropenem, fosfomycin, and polymyxin B strongly increase production of outer membrane vesicles (OMVs) in O104:H4 and O157:H7. Ciprofloxacin also upregulates OMV-associated Shiga toxin 2a, the major virulence factor of these pathogens, whereas the other antibiotics increase OMV production without the toxin. These two effects might worsen the clinical outcome of infections caused by Shiga toxin-producing Our data support the existing recommendations to avoid antibiotics for treatment of these infections.
摘要
环丙沙星、美罗培南、磷霉素和多粘菌素 B 可强烈增加 O104:H4 和 O157:H7 产外膜囊泡（OMVs）。环丙沙星还上调 OMV 相关的志贺毒素 2a，这是这些病原体的主要毒力因子，而其他抗生素则增加 OMV 的产生而不产生毒素。这两种作用可能会使由产志贺毒素的细菌感染引起的临床后果恶化。我们的数据支持现有的建议，即避免使用抗生素治疗这些感染。
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