针对哌拉西林-他唑巴坦耐药/泛β-内酰胺敏感肺炎克雷伯菌菌株，人源化哌拉西林-他唑巴坦暴露的不一致性
Discordance with Humanized Piperacillin-Tazobactam Exposures against Piperacillin-Tazobactam-Resistant/Pan-β-Lactam-Susceptible Klebsiella pneumoniae Strains.
作者信息
Stainton S M, Monogue M L, Nicolau D P
机构信息
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA
出版信息
Antimicrob Agents Chemother. 2017 Jun 27;61(7). doi: 10.1128/AAC.00491-17. Print 2017 Jul.
Abstract
Recent findings have identified strains that are pan-β-lactam susceptible (PBL-S) but piperacillin-tazobactam resistant (TZP-R) We assessed the efficacy of a humanized exposure of piperacillin-tazobactam (TZP) against 12 TZP-R/PBL-S isolates in an immunocompromised murine lung infection model. Discordance between the resistance profile and the efficacy of human-simulated TZP exposures against this phenotypic profile was observed. Additional studies are required to define the clinical implications of these TZP-R/PBL-S strains.
摘要
最近的研究发现了对所有β-内酰胺类药物敏感（PBL-S）但对哌拉西林-他唑巴坦耐药（TZP-R）的菌株。我们在免疫受损的小鼠肺部感染模型中评估了人源化暴露的哌拉西林-他唑巴坦（TZP）对12株TZP-R/PBL-S分离株的疗效。观察到耐药谱与模拟人体TZP暴露对该表型谱的疗效之间存在不一致。需要进一步的研究来确定这些TZP-R/PBL-S菌株的临床意义。
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