Archer C B, Hanson J M, Morley J, MacDonald D M
Acta Derm Venereol Suppl (Stockh). 1985;114:93-7. doi: 10.2340/000155551149397.
Impaired beta-adrenergic and enhanced alpha-adrenergic reactivity have been implicated in the pathogenesis of atopic dermatitis. We have measured the elevation of cyclic AMP in peripheral blood leukocytes in response to isoprenaline, histamine and prostaglandin E2, in the presence and absence of a phosphodiesterase inhibitor. An impaired response to beta-adrenergic stimulation was demonstrated in subjects with atopic dermatitis but impaired responses were also observed with histamine and prostaglandin E2. In vivo, both noradrenaline and salbutamol caused significant inhibition of the histamine-induced weal response in atopic and normal subjects. However, there was no significant difference between the two groups when alpha- and beta-adrenoceptor responses were compared.
β-肾上腺素能反应受损和α-肾上腺素能反应增强与特应性皮炎的发病机制有关。我们在有和没有磷酸二酯酶抑制剂的情况下，测量了外周血白细胞中环磷酸腺苷（cAMP）对异丙肾上腺素、组胺和前列腺素E2的反应升高情况。特应性皮炎患者对β-肾上腺素能刺激的反应受损，但对组胺和前列腺素E2的反应也受损。在体内，去甲肾上腺素和沙丁胺醇均能显著抑制特应性和正常受试者组胺诱导的风团反应。然而，比较α-和β-肾上腺素能受体反应时，两组之间没有显著差异。
