Marazzini L, Bozzoni M, Mastropasqua B, Pelucchi A, Gabrione M
Servizio di Broncopneumologia e Fisiopatologia Respiratoria G. Campari Ospedale Citta di Sesto S. Giovanni, Italy.
Ann Allergy. 1988 May;60(5):407-10.
The role of the adrenergic mechanism in the pathogenesis of atopic diseases is controversial. Recent experimental and clinical reports have suggested that beta-2 adrenergic stimulation impairs and beta-2 adrenergic blockade enhances the histamine effect on vascular permeability. This led us to study the effect of salbutamol and of propranolol on histamine-induced cutaneous response in 13 healthy subjects and in 16 patients with allergic oculo-rhinitis. Both in normal subjects and in atopic patients salbutamol attenuated the whealing response to histamine and the protective effect of salbutamol was counteracted by propranolol. The ability, however, of salbutamol to inhibit histamine-induced response was significantly reduced in 50% of atopic patients. These findings suggest that beta-2 adrenergic hyporesponsiveness is present in some allergic patients.
肾上腺素能机制在特应性疾病发病机制中的作用存在争议。最近的实验和临床报告表明，β-2肾上腺素能刺激会损害，而β-2肾上腺素能阻断会增强组胺对血管通透性的作用。这促使我们研究沙丁胺醇和普萘洛尔对13名健康受试者和16名过敏性眼鼻炎患者组胺诱导的皮肤反应的影响。在正常受试者和特应性患者中，沙丁胺醇均减弱了对组胺的风团反应，且沙丁胺醇的保护作用被普萘洛尔抵消。然而，50%的特应性患者中，沙丁胺醇抑制组胺诱导反应的能力显著降低。这些发现表明，一些过敏患者存在β-2肾上腺素能低反应性。
