Assem E S
Br J Pharmacol. 1974 Oct;52(2):213-8. doi: 10.1111/j.1476-5381.1974.tb09702.x.
1 The effects of alpha- and beta-adrenoceptor stimulants on the histamine-forming capacity (HFC) of human isolated leucocytes have been studied, in vitro.2 It was confirmed that antigen significantly stimulates the HFC of human leucocytes.3 beta-Adrenoceptor stimulants, such as isoprenaline and salbutamol (10(-6)-10(-3)M) significantly inhibited the HFC of human leucocytes in the presence and absence of antigen. At concentrations lower than 10(-6)M, this effect was not observed. In general the degree of inhibition of HFC by beta-adrenoceptor stimulants followed their potency as beta-adrenoceptor stimulants.4 alpha-Adrenoceptor stimulants significantly stimulated leucocyte HFC; noradrenaline within a limited concentration of 10(-6)M, while stimulation was seen consistently with phenylephrine at concentrations of 10(-7)-10(-4)M. Adrenaline, which stimulates both alpha- and beta-adrenoceptors, produced small inhibition, no effect, or a degree of stimulation.5 Phentolamine, an alpha-adrenoceptor blocking agent, produced an effect opposite to that of the alpha-adrenoceptor stimulants, i.e. a significant inhibition of the HFC of human isolated leucocytes.
已经在体外研究了α-和β-肾上腺素能受体兴奋剂对人离体白细胞组胺生成能力（HFC）的影响。
证实抗原能显著刺激人白细胞的HFC。
β-肾上腺素能受体兴奋剂，如异丙肾上腺素和沙丁胺醇（10⁻⁶ - 10⁻³M），在有和没有抗原存在的情况下，均能显著抑制人白细胞的HFC。在低于10⁻⁶M的浓度下，未观察到这种效应。一般来说，β-肾上腺素能受体兴奋剂对HFC的抑制程度与其作为β-肾上腺素能受体兴奋剂的效力一致。
α-肾上腺素能受体兴奋剂能显著刺激白细胞HFC；去甲肾上腺素在10⁻⁶M的有限浓度范围内，而苯肾上腺素在10⁻⁷ - 10⁻⁴M的浓度下持续观察到刺激作用。肾上腺素既能刺激α-又能刺激β-肾上腺素能受体，产生轻微抑制、无作用或一定程度的刺激。
酚妥拉明，一种α-肾上腺素能受体阻断剂，产生了与α-肾上腺素能受体兴奋剂相反的作用，即显著抑制人离体白细胞的HFC。
