Minhas Sadia, Kashif Muhammad, Altaf Wasif, Afzal Nadeem, Nagi Abdul Hanan
Oral Pathology Department, Akhtar Saeed Medical and Dental College, Lahore 54000, Pakistan.
Cancer Biol Med. 2017 May;14(2):176-182. doi: 10.20892/j.issn.2095-3941.2016.0096.
: Oral squamous-cell carcinoma (OSCC) accounts for >90% of oral cancers affecting adults mostly between the fourth to seventh decades of life. The most common OSCC treatment is concomitant chemoradiotherapy (CCRT) having both loco-regional and distant control, but CCRT has acute and chronic toxic effects on adjacent normal tissue. This study aimed to determine the side effects of CCRT on the oral mucosa and to characterize the clinicopathology of oral lesions in patients with OSCC.
This descriptive, cross-sectional study was certified by the Ethical Review Committee (UHS/Education/126-12/2728) of the University of Health Sciences, Lahore, Pakistan. OSSC patients (=81) with various histological subtypes, grades, and stages were recruited, and findings on their oral examination were recorded. These patients received 70, 90, and 119 Gy of radiotherapy dosages in combination with the chemotherapy drugs cisplatin and 5-fluorouracil. Data were analyzed using SPSS 20.0.
: The most common presentation of OSCC was a nonhealing ulcer (63%) involving tongue (55.6%). Clinical findings included mucositis (92.6%) and xerostomia of mild, moderate, and severe degrees in 11.1%, 46.9%, and 35.8% cases, respectively. Ulcers (87.7%), palpable lymph nodes (64.2%), limited mouth opening (64.2%) and fistula (40.7%) were also observed. In females, the association of radiotherapy dosage with limited mouth opening, xerostomia, and histological grading was statistically significant (<0.05). The association of chemotherapy drugs with xerostomia (=0.003) was also statistically significant.
: CCRT induced mucositis, xerostomia, and trismus in patients with OSCC.
口腔鳞状细胞癌（OSCC）占影响成年人的口腔癌的90%以上，主要发生在40至70岁之间。OSCC最常见的治疗方法是同步放化疗（CCRT），它对局部和远处都有控制作用，但CCRT对相邻正常组织有急性和慢性毒性作用。本研究旨在确定CCRT对口腔黏膜的副作用，并对OSCC患者口腔病变的临床病理特征进行描述。
这项描述性横断面研究得到了巴基斯坦拉合尔健康科学大学伦理审查委员会（UHS/教育/126 - 12/2728）的认证。招募了81例具有各种组织学亚型、分级和分期的OSCC患者，并记录他们口腔检查的结果。这些患者接受了70、90和119 Gy的放射治疗剂量，并联合化疗药物顺铂和5 - 氟尿嘧啶。使用SPSS 20.0对数据进行分析。
OSCC最常见的表现是不愈合溃疡（63%），累及舌部（55.6%）。临床发现包括口腔黏膜炎（92.6%），口干程度为轻度、中度和重度的病例分别占11.1%、46.9%和35.8%。还观察到溃疡（87.7%）、可触及淋巴结（64.2%）、张口受限（64.2%）和瘘管（40.7%）。在女性中，放射治疗剂量与张口受限、口干和组织学分级之间的关联具有统计学意义（<0.05）。化疗药物与口干之间的关联（=0.003）也具有统计学意义。
CCRT可导致OSCC患者出现口腔黏膜炎、口干和张口受限。
