Li Enhong, Zeng Jiang, Hong Feiruo, Chen Piaopiao, Yu Xuefen
School of Medicine, Zhejiang University, Hangzhou, 310058, China.
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, 310000, China.
Clin Transl Oncol. 2025 Apr;27(4):1767-1778. doi: 10.1007/s12094-024-03706-y. Epub 2024 Sep 14.
Although the discussion about oral mucositis in Head and Neck Cancer (HNC) patients has become a prominent issue, its incidence and influencing factors have not been thoroughly synthesized. This meta-analysis aims to integrate the prevalence and associated factors of radiation-induced oral mucositis among HNC patients.
This study searched the following electronic databases: PubMed, the Cochrane Database, the Web of Science, EMBASE, CNKI, the Wanfang Database, and the VIP Database. The publication timeframe for the included studies ranged from January 2005 until January 2024. Two investigators used the NOS scale and AHRQ evaluation criteria for quality evaluation. All qualified studies and statistical analyses were conducted using RevMan 5.2 and Stata 17.0.
Thirty eligible studies were included in the analysis. The results show that the prevalence of radiation-induced oral mucositis in HNC patients was 94% [95% CI (89%, 98%)]. Furthermore, the prevalence of severe radiation-induced oral mucositis in HNC patients is 37% [95%CI (29%, 45%)]. Chemotherapy, smoking history, diabetes, oral PH ≤ 7.0, and alcohol consumption are the main risk factors for radioactive oral mucositis. In addition, BMI > 24.0 kg/m, no use of antibiotics, and no use of oral mucosal protective agents are associated with radioactive oral mucositis.
This meta-analysis underscores a significantly high prevalence of radiation-induced oral mucositis in HNC patients. Establishing healthy lifestyle habits and maintaining a healthy oral environment are pivotal in preventing radiation-induced oral mucositis.
尽管头颈部癌（HNC）患者口腔黏膜炎的讨论已成为一个突出问题，但其发病率和影响因素尚未得到全面综合。本荟萃分析旨在整合HNC患者放射性口腔黏膜炎的患病率及相关因素。
本研究检索了以下电子数据库：PubMed、Cochrane数据库、Web of Science、EMBASE、中国知网、万方数据库和维普数据库。纳入研究的发表时间范围为2005年1月至2024年1月。两名研究者使用NOS量表和AHRQ评估标准进行质量评估。所有合格研究和统计分析均使用RevMan 5.2和Stata 17.0进行。
30项符合条件的研究纳入分析。结果显示，HNC患者放射性口腔黏膜炎的患病率为94%[95%CI（89%，98%）]。此外，HNC患者严重放射性口腔黏膜炎的患病率为37%[95%CI（29%，45%）]。化疗、吸烟史、糖尿病、口腔pH值≤7.0和饮酒是放射性口腔黏膜炎的主要危险因素。此外，BMI>24.0 kg/m²、未使用抗生素和未使用口腔黏膜保护剂与放射性口腔黏膜炎有关。
本荟萃分析强调HNC患者放射性口腔黏膜炎的患病率显著较高。建立健康的生活习惯和保持健康的口腔环境对预防放射性口腔黏膜炎至关重要。
