Wang Peipei, Wang Jie, Ma Jun, Jin Ge, Guan Xueqiang
Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Xueyuanxi Road, No. 109, Wenzhou, Zhejiang 325000, China.
Department of Neurology, Wenzhou City Hospital of Traditional Chinese Medicine and Western Medicine Combined, Wenzhou, China.
Biomed Res Int. 2017;2017:3489603. doi: 10.1155/2017/3489603. Epub 2017 May 18.
Studies have investigated the association between age-related macular degeneration (AMD) and subsequent risks of mortality, but results have been equivocal. We conducted a comprehensive analysis of prospective cohort studies to assess the association of AMD and the risk of mortality in the general population. We searched PubMed and EMBASE for trials published from 1980 to 2016. We included 11 cohort studies that reported relative risks with 95% confidence intervals for the association of AMD and mortality, involving 57,069 participants. In a random-effects model, the adjusted RR (95% confidence interval) associated with AMD was 1.09 (1.02-1.17) for all-cause mortality. Findings from this research provide support that persons with AMD had a higher subsequent risk of mortality than persons without AMD.
已有研究探讨了年龄相关性黄斑变性（AMD）与后续死亡风险之间的关联，但结果并不明确。我们对前瞻性队列研究进行了全面分析，以评估AMD与普通人群死亡风险之间的关联。我们在PubMed和EMBASE中检索了1980年至2016年发表的试验。我们纳入了11项队列研究，这些研究报告了AMD与死亡率关联的相对风险及95%置信区间，涉及57069名参与者。在随机效应模型中，AMD相关的全因死亡率调整后RR（95%置信区间）为1.09（1.02 - 1.17）。本研究结果支持了患有AMD的人比未患AMD的人后续死亡风险更高这一观点。
