胆碱能增强的行为认知靶点。
Behavioral-Cognitive Targets for Cholinergic Enhancement.
作者信息
Sarter Martin
机构信息
University of Michigan, Department of Psychology, 4030 East Hall, 530 Church Street, Ann Arbor, MI 48109.
出版信息
Curr Opin Behav Sci. 2015 Aug;4:22-26. doi: 10.1016/j.cobeha.2015.01.004. Epub 2015 Jan 15.
Abstract
Cholinergic mechanisms have long been considered a promising target for enhancing cognitive functions. Two distinct yet interacting components of cholinergic activity have been proposed to mediate specific cognitive functions. Transient spikes in cholinergic activity mediate the detection of cues in situations involving attentional mode shifts. More slowly changing cholinergic neuromodulation of cortical circuitry regulates task compliance specifically in response to performance challenges. Increases in cholinergic neuromodulation enhances the generation of cholinergic transients via stimulation of α4β2* nicotinic acetylcholine receptors. Stimulation of these receptors stabilizes attentional performance and increases cue detection rates. Adjunctive treatment with agonists or modulators at these receptors is predicted to benefit unstable attentional performance and low cue detection rates that are common to several brain disorders.
摘要
长期以来，胆碱能机制一直被认为是增强认知功能的一个有前景的靶点。胆碱能活动有两个不同但相互作用的组成部分，它们被认为介导特定的认知功能。胆碱能活动中的短暂峰值介导了在涉及注意力模式转换的情况下对线索的检测。胆碱能对皮质回路的更缓慢变化的神经调节则专门在应对性能挑战时调节任务依从性。胆碱能神经调节的增加通过刺激α4β2*烟碱型乙酰胆碱受体增强胆碱能瞬变的产生。刺激这些受体会稳定注意力表现并提高线索检测率。预计用这些受体的激动剂或调节剂进行辅助治疗将有益于几种脑部疾病常见的不稳定注意力表现和低线索检测率。
相似文献
1
Behavioral-Cognitive Targets for Cholinergic Enhancement.胆碱能增强的行为认知靶点。
Curr Opin Behav Sci. 2015 Aug;4:22-26. doi: 10.1016/j.cobeha.2015.01.004. Epub 2015 Jan 15.
2
Deficits in attentional control: cholinergic mechanisms and circuitry-based treatment approaches.注意力控制缺陷：胆碱能机制及基于神经回路的治疗方法
Behav Neurosci. 2011 Dec;125(6):825-35. doi: 10.1037/a0026227.
3
Cholinergic double duty: cue detection and attentional control.胆碱能双重任务：提示检测和注意力控制。
Curr Opin Psychol. 2019 Oct;29:102-107. doi: 10.1016/j.copsyc.2018.12.026. Epub 2019 Jan 4.
4
Deterministic functions of cortical acetylcholine.皮层乙酰胆碱的确定性功能。
Eur J Neurosci. 2014 Jun;39(11):1912-20. doi: 10.1111/ejn.12515. Epub 2014 Mar 4.
5
Cholinergic mediation of attention: contributions of phasic and tonic increases in prefrontal cholinergic activity.胆碱能对注意力的调节作用：前额叶胆碱能活性的相位性和持续性增加所起的作用。
Ann N Y Acad Sci. 2008;1129:225-35. doi: 10.1196/annals.1417.021.
6
Acetylcholine Release in Prefrontal Cortex Promotes Gamma Oscillations and Theta-Gamma Coupling during Cue Detection.前额叶皮质中的乙酰胆碱释放促进线索检测过程中的γ振荡和θ-γ耦合。
J Neurosci. 2017 Mar 22;37(12):3215-3230. doi: 10.1523/JNEUROSCI.2737-16.2017. Epub 2017 Feb 17.
7
Cortical cholinergic signaling controls the detection of cues.皮质胆碱能信号传导控制线索的检测。
Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1089-97. doi: 10.1073/pnas.1516134113. Epub 2016 Jan 19.
8
What do phasic cholinergic signals do?阶段性胆碱能信号有什么作用？
Neurobiol Learn Mem. 2016 Apr;130:135-41. doi: 10.1016/j.nlm.2016.02.008. Epub 2016 Feb 18.
9
Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection.揭示皮质胆碱能输入的注意力功能：信号驱动与信号检测认知调制之间的相互作用。
Brain Res Brain Res Rev. 2005 Feb;48(1):98-111. doi: 10.1016/j.brainresrev.2004.08.006.
10
More attention must be paid: the neurobiology of attentional effort.必须给予更多关注：注意力努力的神经生物学。
Brain Res Rev. 2006 Aug;51(2):145-60. doi: 10.1016/j.brainresrev.2005.11.002. Epub 2006 Mar 13.
引用本文的文献
1
Cognitive Effects of a Cognitive Stimulation Programme on Trained Domains in Older Adults with Subjective Memory Complaints: Randomised Controlled Trial.认知刺激方案对有主观记忆抱怨的老年受训领域的认知影响：随机对照试验。
Int J Environ Res Public Health. 2023 Feb 18;20(4):3636. doi: 10.3390/ijerph20043636.
2
Basal Forebrain Chemogenetic Inhibition Converts the Attentional Control Mode of Goal-Trackers to That of Sign-Trackers.基底前脑化学遗传抑制将目标追踪者的注意控制模式转换为信号追踪者的注意控制模式。
eNeuro. 2022 Dec 26;9(6). doi: 10.1523/ENEURO.0418-22.2022. Print 2022 Nov-Dec.
3
Prenatal choline supplementation improves child sustained attention: A 7-year follow-up of a randomized controlled feeding trial.产前补充胆碱可改善儿童持续注意力：一项随机对照喂养试验的 7 年随访研究。
FASEB J. 2022 Jan;36(1):e22054. doi: 10.1096/fj.202101217R.
4
Roles of the Functional Interaction between Brain Cholinergic and Dopaminergic Systems in the Pathogenesis and Treatment of Schizophrenia and Parkinson's Disease.脑胆碱能和多巴胺能系统功能相互作用在精神分裂症和帕金森病发病机制和治疗中的作用。
Int J Mol Sci. 2021 Apr 21;22(9):4299. doi: 10.3390/ijms22094299.
5
Contrasting effects of the α7 nicotinic receptor antagonist methyllycaconitine in different rat models of heroin reinstatement.α7 烟碱型乙酰胆碱受体拮抗剂甲基戊烯莨菪碱在不同海洛因复吸大鼠模型中的对比作用。
J Psychopharmacol. 2021 Oct;35(10):1204-1215. doi: 10.1177/0269881121991570. Epub 2021 Mar 10.
6
Make a Left Turn: Cortico-Striatal Circuitry Mediating the Attentional Control of Complex Movements.向左转：介导复杂运动注意力控制的皮质-纹状体回路。
Mov Disord. 2021 Mar;36(3):535-546. doi: 10.1002/mds.28532. Epub 2021 Feb 22.
7
Rescuing the attentional performance of rats with cholinergic losses by the M1 positive allosteric modulator TAK-071.通过 M1 正变构调节剂 TAK-071 挽救胆碱能缺失大鼠的注意力表现。
Psychopharmacology (Berl). 2020 Jan;237(1):137-153. doi: 10.1007/s00213-019-05354-5. Epub 2019 Oct 16.
8
Cholinergic double duty: cue detection and attentional control.胆碱能双重任务：提示检测和注意力控制。
Curr Opin Psychol. 2019 Oct;29:102-107. doi: 10.1016/j.copsyc.2018.12.026. Epub 2019 Jan 4.
9
Co-treatment with rivastigmine and idalopirdine reduces the propensity for falls in a rat model of falls in Parkinson's disease.联合使用利伐斯的明和依达拉奉可降低帕金森病跌倒模型大鼠跌倒倾向。
Psychopharmacology (Berl). 2019 Jun;236(6):1701-1715. doi: 10.1007/s00213-018-5150-y. Epub 2019 Jan 4.
10
Cholinergic modulation of spatial learning, memory and navigation.胆碱能调制空间学习、记忆和导航。
Eur J Neurosci. 2018 Sep;48(5):2199-2230. doi: 10.1111/ejn.14089. Epub 2018 Aug 19.
本文引用的文献
1
Interpreting chemical neurotransmission in vivo: techniques, time scales, and theories.体内化学神经传递的解读：技术、时间尺度与理论
ACS Chem Neurosci. 2015 Jan 21;6(1):8-10. doi: 10.1021/cn500319m. Epub 2014 Dec 16.
2
Where attention falls: Increased risk of falls from the converging impact of cortical cholinergic and midbrain dopamine loss on striatal function.注意力下降：皮质胆碱能和中脑多巴胺丧失对纹状体功能的汇聚影响导致跌倒风险增加。
Exp Neurol. 2014 Jul;257:120-9. doi: 10.1016/j.expneurol.2014.04.032. Epub 2014 May 5.
3
Disposed to distraction: genetic variation in the cholinergic system influences distractibility but not time-on-task effects.易受干扰：胆碱能系统的基因变异影响易分心程度，但不影响任务持续时间效应。
J Cogn Neurosci. 2014 Sep;26(9):1981-91. doi: 10.1162/jocn_a_00607. Epub 2014 Mar 25.
4
Deterministic functions of cortical acetylcholine.皮层乙酰胆碱的确定性功能。
Eur J Neurosci. 2014 Jun;39(11):1912-20. doi: 10.1111/ejn.12515. Epub 2014 Mar 4.
5
An opportunity cost model of subjective effort and task performance.主观努力与任务绩效的机会成本模型。
Behav Brain Sci. 2013 Dec;36(6):661-79. doi: 10.1017/S0140525X12003196.
6
Muscarinic signaling in the brain.脑内毒蕈碱型乙酰胆碱受体信号转导
Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.
7
Prefrontal cholinergic mechanisms instigating shifts from monitoring for cues to cue-guided performance: converging electrochemical and fMRI evidence from rats and humans.前额胆碱能机制促使从线索监测到线索引导的表现转变：来自大鼠和人类的电化学和 fMRI 证据的融合。
J Neurosci. 2013 May 15;33(20):8742-52. doi: 10.1523/JNEUROSCI.5809-12.2013.
8
Cholinergic control over attention in rats prone to attribute incentive salience to reward cues.大鼠胆碱能系统对注意的控制：易将奖励线索归因于激励价值。
J Neurosci. 2013 May 8;33(19):8321-35. doi: 10.1523/JNEUROSCI.0709-13.2013.
9
A randomized, double-blind, placebo-controlled phase 2 study of α4β2 agonist ABT-894 in adults with ADHD.一项随机、双盲、安慰剂对照的 2 期研究，评估 α4β2 激动剂 ABT-894 治疗成人注意缺陷多动障碍（ADHD）的疗效。
Neuropsychopharmacology. 2013 Feb;38(3):405-13. doi: 10.1038/npp.2012.194. Epub 2012 Oct 3.
10
Revitalizing psychiatric drug discovery.重振精神科药物研发。
Nat Rev Drug Discov. 2012 Jun 1;11(6):423-4. doi: 10.1038/nrd3755.
Zotero 插件