中性粒细胞与淋巴细胞比值在特发性视网膜前膜中的意义。
The significance of neutrophil-to-lymphocyte ratio in idiopathic epiretinal membrane.
作者信息
Dikkaya Funda, Karaman Erdur Sevil, Ozsutcu Mustafa, Aydin Rukiye, Kocabora Mehmet Selim, Aras Cengiz
机构信息
Department of Ophthalmology, Istanbul Medipol University, Istanbul, 34214, Turkey.
出版信息
Int Ophthalmol. 2018 Aug;38(4):1393-1397. doi: 10.1007/s10792-017-0597-0. Epub 2017 Jun 12.
PURPOSE
To assess the levels of neutrophil-to-lymphocyte ratio (NLR) in patients with idiopathic epiretinal membrane (iERM) and to compare the NLR results of patients with iERM and healthy controls.
METHODS
This retrospective study enrolled 43 patients with iERM and 40 healthy subjects. Complete ophthalmologic examination and complete blood count measurements were performed of all subjects. Complete blood counts were performed within 2 h of blood collection.
RESULTS
There was a significant difference in NLR between iERM and control groups (p < 0.01). The receiver operating characteristics analysis revealed that the value of NLR to distinguish patients with iERM and controls was found to be 0.832. The best cutoff value was 1.90, with a sensitivity of 72% and specificity 70%.
CONCLUSIONS
Our study for the first time provides evidence that subclinical systemic inflammation may cause or at least accompanies iERM using a novel biomarker NLR.
目的
评估特发性视网膜前膜（iERM）患者的中性粒细胞与淋巴细胞比值（NLR）水平，并比较iERM患者与健康对照者的NLR结果。
方法
这项回顾性研究纳入了43例iERM患者和40名健康受试者。对所有受试者进行了全面的眼科检查和全血细胞计数测量。全血细胞计数在采血后2小时内进行。
结果
iERM组与对照组之间的NLR存在显著差异（p < 0.01）。受试者工作特征分析显示，NLR区分iERM患者与对照组的值为0.832。最佳截断值为1.90，敏感性为72%，特异性为70%。
结论
我们的研究首次提供了证据，表明使用新型生物标志物NLR，亚临床全身炎症可能导致或至少伴随iERM。
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