特发性视网膜前膜患者中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值及平均血小板体积的评估
Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and mean platelet volume in patients with idiopathic epiretinal membrane.
作者信息
Demir Gokhan, Topcu Husna, Cakmak Semih, Aksoy Funda Ebru, Sucu Mehmet Emin, Gunes Hasan, Yasa Dilek, Alkın Zeynep
机构信息
The University of Health Sciences, Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.
Inebolu State Hospital, 37000, Kastamonu, Turkey.
出版信息
Ther Adv Ophthalmol. 2021 Apr 23;13:25158414211010546. doi: 10.1177/25158414211010546. eCollection 2021 Jan-Dec.
PURPOSE
To assess the role of inflammation in the pathogenesis of idiopathic epiretinal membrane (iERM) using the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) as indicators of inflammation and to compare these parameter levels between iERM and control subjects.
METHODS
We retrospectively analyzed the medical records of 36 patients who underwent vitrectomy-ERM peeling and 39 patients who had cataract surgery. We obtained blood samples from all individuals who participated in the study to investigate these parameters.
RESULTS
Seventy-five subjects were included in this study: 36 in the iERM group and 39 in the control group. The mean neutrophil and MPV levels were significantly higher in iERM subjects than in control subjects. The mean lymphocyte level was lower in the iERM group. The mean NLR, PLR, and MPV levels were higher in iERM subjects than in control subjects.
CONCLUSION
The higher NLR, PLR, and MPV levels found in patients with iERM may indicate that subclinical systemic inflammation may associate with iERM.
目的
以中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）及平均血小板体积（MPV）作为炎症指标，评估炎症在特发性视网膜前膜（iERM）发病机制中的作用，并比较iERM患者与对照者的这些参数水平。
方法
我们回顾性分析了36例行玻璃体切除术-视网膜前膜剥除术患者及39例行白内障手术患者的病历。我们从所有参与研究的个体中采集血样以检测这些参数。
结果
本研究共纳入75名受试者：iERM组36名，对照组39名。iERM患者的中性粒细胞平均水平和MPV显著高于对照者。iERM组的淋巴细胞平均水平较低。iERM患者的NLR、PLR及MPV平均水平高于对照者。
结论
iERM患者中较高的NLR、PLR及MPV水平可能表明亚临床全身炎症可能与iERM有关。
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