State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology , Qingdao 266042, China.
State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research Institute (LSMRI) , Qingdao 266101, P. R. China.
J Org Chem. 2017 Jul 7;82(13):7015-7022. doi: 10.1021/acs.joc.7b00907. Epub 2017 Jun 21.
A novel Mn(II)-promoted tandem phosphorylation/cyclization reaction of 2-biaryl isothiocyanates with phosphine oxides is described. This is the first general method to synthesize 6-phosporylated phenanthridines from 2-biaryl isothiocyanates. The approach is featured by oxidant-free, low loading of P-reagent, easy operation, and high functional group tolerance.
本文描述了一种新型的 Mn(II)促进的 2-联芳基异硫氰酸酯与氧化膦的串联磷酸化/环化反应。这是首次从 2-联芳基异硫氰酸酯合成 6-磷酸化菲啶的通用方法。该方法具有无氧化剂、低 P 试剂用量、操作简单、官能团容忍度高等特点。
