苯巴比妥可增加青蛙神经肌肉接头处的自发递质释放。
Phenobarbital increases spontaneous transmitter release at the frog neuromuscular junction.
作者信息
Pincus J H, Insler N F
出版信息
Yale J Biol Med. 1978 Mar-Apr;51(2):185-9.
Abstract
Phenobarbital (1-2 × 10(-4)M) markedly increases the frequency of miniature end-plate potentials at the neuromuscular synapse of the frog. This effect was seen in calcium free media containing EGTA. The drug probably acts presynaptically at an intracellular locus to increase the presynaptic free calcium concentration.
摘要
苯巴比妥（1 - 2×10⁻⁴M）可显著增加青蛙神经肌肉突触处微小终板电位的频率。在含有乙二醇双四乙酸（EGTA）的无钙培养基中也观察到了这种效应。该药物可能在细胞内位点通过突触前作用来增加突触前游离钙浓度。
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本文引用的文献
1
The effect of anesthetic agents on skeletal muscle membrane.麻醉剂对骨骼肌膜的作用。
Acta Physiol Scand. 1956 Nov 5;37(4):335-49. doi: 10.1111/j.1748-1716.1956.tb01369.x.
2
Tetrodotoxin and neuromuscular transmission.河豚毒素与神经肌肉传递
Proc R Soc Lond B Biol Sci. 1967 Jan 31;167(1006):8-22. doi: 10.1098/rspb.1967.0010.
3
The release of acetylcholine from nerve endings by graded electric pulses.通过分级电脉冲使乙酰胆碱从神经末梢释放。
Proc R Soc Lond B Biol Sci. 1967 Jan 31;167(1006):23-38. doi: 10.1098/rspb.1967.0011.
4
Barbiturate-induced transmitter release at a frog neuromuscular junction.巴比妥酸盐诱导的青蛙神经肌肉接头处的递质释放。
Br J Pharmacol. 1973 May;48(1):48-58. doi: 10.1111/j.1476-5381.1973.tb08221.x.
5
Barbiturate-induced changes in transmitter release independent of terminal spike configuration in the frog neuromuscular junction.巴比妥酸盐引起的蛙神经肌肉接头处递质释放的变化与终末锋电位形态无关。
Neuropharmacology. 1977 Jul-Aug;16(7-8):507-9. doi: 10.1016/0028-3908(77)90009-0.
6
A comparison of the presynaptic and post-synaptic actions of pentobarbitone and phenobarbitone in the neuromuscular junction of the frog.戊巴比妥和苯巴比妥在青蛙神经肌肉接头处的突触前和突触后作用比较。
J Physiol. 1976 Jun;258(1):257-68. doi: 10.1113/jphysiol.1976.sp011418.
7
Mechanism of blockade of neuromuscular transmission by pentobarbital.戊巴比妥阻断神经肌肉传递的机制。
J Pharmacol Exp Ther. 1975 Jan;192(1):95-104.
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