Branisteanu D D, Volle R L
J Pharmacol Exp Ther. 1975 Aug;194(2):362-72.
Complete or partial replacement of Na+ by Li+ resulted in a progressively developing increase in the amplitude and quantal content of end-plate potentials of the frog neuromuscular junction. Analysis of frequency facilitation curves and estimations of the binomial parameters of release indicate that Li+ caused an increase in the probability of transmitter release. Li+ also caused a time dependent increase in the frequency of miniature end-plate potentials. The responsiveness of the miniature end-plate potentials to Li+ was depressed by elevated Ca++ and enhanced by elevated K+. Collectively, the effects of Li+ on transmitter release can be attributed to the accumulation by the nerve terminals of Li+ resulting on an increased level of intracellular Ca++.
用Li⁺完全或部分替代Na⁺导致青蛙神经肌肉接头终板电位的幅度和量子含量逐渐增加。对频率易化曲线的分析以及对释放的二项式参数的估计表明，Li⁺导致递质释放概率增加。Li⁺还导致微小终板电位频率随时间增加。微小终板电位对Li⁺的反应性在Ca²⁺升高时受到抑制，在K⁺升高时增强。总体而言，Li⁺对递质释放的影响可归因于神经末梢对Li⁺的积累，导致细胞内Ca²⁺水平升高。
