Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, VA, USA.
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA, USA.
Mol Oral Microbiol. 2017 Dec;32(6):446-454. doi: 10.1111/omi.12190. Epub 2017 Aug 1.
Even though the oral microbiome is one of the most complex sites on the body it is an excellent model for narrow-spectrum antimicrobial therapy. Current research indicates that disruption of the microbiome leads to a dysbiotic environment allowing for the overgrowth of pathogenic species and the onset of oral diseases. The gram-negative colonizer, Porphyromonas gingivalis has long been considered a key player in the initiation of periodontitis and Streptococcus mutans has been linked to dental caries. With antibiotic research still on the decline, new strategies are greatly needed to combat infectious diseases. By targeting key pathogens, it may be possible to treat oral infections while allowing for the recolonization of the beneficial, healthy flora. In this review, we examine unique strategies to specifically target periodontal pathogens and address what is needed for the success of these approaches in the microbiome era.
尽管口腔微生物组是人体中最复杂的部位之一，但它是窄谱抗菌治疗的绝佳模型。目前的研究表明，微生物组的破坏会导致生态失调，有利于病原物种的过度生长和口腔疾病的发生。革兰氏阴性定植菌牙龈卟啉单胞菌长期以来一直被认为是牙周炎发病的关键因素，而变形链球菌则与龋齿有关。随着抗生素研究的持续下降，急需新的策略来对抗传染病。通过针对关键病原体，有可能在允许有益健康的菌群重新定植的情况下治疗口腔感染。在这篇综述中，我们研究了专门针对牙周病原体的独特策略，并探讨了在微生物组时代这些方法取得成功所需的条件。
