SPX-101 Is a Promising and Novel Nebulized ENaC Inhibitor.
作者信息
Lennox Alison, Myerburg Mike M
机构信息
1 Division of Pulmonary, Allergy, and Critical Care Medicine University of Pittsburgh Pittsburgh, Pennsylvania.
出版信息
Am J Respir Crit Care Med. 2017 Sep 15;196(6):671-672. doi: 10.1164/rccm.201705-0928ED.
Abstract
摘要
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本文引用的文献
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2
Acidic pH increases airway surface liquid viscosity in cystic fibrosis.酸性pH值会增加囊性纤维化患者气道表面液体的粘度。
J Clin Invest. 2016 Mar 1;126(3):879-91. doi: 10.1172/JCI83922. Epub 2016 Jan 25.
3
Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures.鉴定 SPLUNC1 对 ENaC 的抑制结构域为囊性纤维化气道上皮细胞培养中钠过度吸收的治疗提供了新策略。
Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L990-L1001. doi: 10.1152/ajplung.00103.2013. Epub 2013 Oct 11.
4
Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways.囊性纤维化气道中 pH 依赖性黏膜脱水的分子基础。
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):15973-8. doi: 10.1073/pnas.1311999110. Epub 2013 Sep 16.
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Acute hyperkalemia associated with inhalation of a potent ENaC antagonist: Phase 1 trial of GS-9411.与强效上皮钠通道拮抗剂吸入相关的急性高钾血症：GS-9411的1期试验
J Aerosol Med Pulm Drug Deliv. 2014 Jun;27(3):200-8. doi: 10.1089/jamp.2013.1037. Epub 2013 Aug 1.
6
The cystic fibrosis transmembrane conductance regulator impedes proteolytic stimulation of the epithelial Na+ channel.囊性纤维化跨膜电导调节因子抑制上皮钠通道的蛋白水解刺激。
J Biol Chem. 2010 Oct 15;285(42):32227-32. doi: 10.1074/jbc.M110.155259. Epub 2010 Aug 13.
7
SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes.SPLUNC1 表达降低非洲爪蟾卵母细胞上皮钠离子通道 (ENaC) 的表面水平。
Channels (Austin). 2010 Jul-Aug;4(4):255-9. doi: 10.4161/chan.4.4.12255. Epub 2010 Jul 4.
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SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage.SPLUNC1通过保护上皮钠通道（ENaC）免受蛋白水解切割来调节气道表面液体量。
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Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis.气道表面液体量通过改变丝氨酸蛋白酶-蛋白酶抑制剂平衡来调节上皮钠通道：一种囊性纤维化中钠过度吸收的机制。
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Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia.在正常和囊性纤维化的气道表面上皮中，决定气道表面液体量的是可溶性介质，而非纤毛。
J Gen Physiol. 2006 May;127(5):591-604. doi: 10.1085/jgp.200509468.
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