Zeinali Majid, Rezaee Seyed Abdolrahim, Hosseinzadeh Hossein
Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences (MUMS), Mashhad, Islamic Republic of Iran; Social Security Organization (SSO), Mashhad, Islamic Republic of Iran.
Inflammation and Inflammatory Diseases Research Center, Mashhad University of Medical Science (MUMS), Mashhad, Islamic Republic of Iran.
Biomed Pharmacother. 2017 Aug;92:998-1009. doi: 10.1016/j.biopha.2017.06.003. Epub 2017 Jun 9.
Inflammation and the pro-inflammatory cytokines are associated with numerous chronic diseases. Studies suggest that flavonoids, plant polyphenolic compound derivatives from natural origin, have a wide range of putative biological activities. Similar to other flavonoids, chrysin (CH) by its anti-oxidative and anti-inflammatory effects is a potential prophylactic agent in immunopathological and physicochemical injuries. This is an overview on putative immunomodulatory activities of flavonoids and beneficial health effects of these substances particularly, CH in the immune system. CH possesses potent immune-protective effects and suppresses inflammation in innate immune system which results to avoid damages induced by neutrophils and macrophages and suppresses immuno-inflammatory responses. Furthermore, beneficial effects of chrysin on inhibition of serum levels nuclear transcription factor κB (NF-κB) p65 unit, tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), IL-6, IL-12, IL-17A, interferon gamma (IFN-γ) was reported. Moreover, CH has been known as the antagonist of NF-kB and the agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ) which in down regulation of the key pro-inflammatory enzymes such as myeloperoxidase (MPO), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), phospholipase A2, and prostanoids. Therefore, CH can improve immune system and neurodegenerative diseases. In recent years, there has been an increasing interest in compound derivatives from natural origin. Taken together, evidences show that flavonoids may have health-promoting and disease-preventing dietary compounds with important benefits in modern life styles.
炎症和促炎细胞因子与多种慢性疾病相关。研究表明，黄酮类化合物，即源自天然的植物多酚类化合物衍生物，具有广泛的假定生物活性。与其他黄酮类化合物类似，白杨素（CH）凭借其抗氧化和抗炎作用，在免疫病理和物理化学损伤中是一种潜在的预防剂。这是一篇关于黄酮类化合物假定的免疫调节活性以及这些物质，特别是CH在免疫系统中的有益健康作用的综述。CH具有强大的免疫保护作用，并抑制先天性免疫系统中的炎症，从而避免中性粒细胞和巨噬细胞诱导的损伤，并抑制免疫炎症反应。此外，据报道白杨素对抑制血清中核转录因子κB（NF-κB）p65亚基、肿瘤坏死因子α（TNF-α）、白细胞介素-1β（IL-1β）、IL-6、IL-12、IL-17A、干扰素γ（IFN-γ）水平有有益作用。此外，CH已知是NF-κB的拮抗剂和过氧化物酶体增殖物激活受体γ（PPAR-γ）的激动剂，可下调关键促炎酶，如髓过氧化物酶（MPO）、环氧化酶-2（COX-2）、诱导型一氧化氮合酶（iNOS）、磷脂酶A2和前列腺素。因此，CH可以改善免疫系统和神经退行性疾病。近年来，人们对天然来源的化合物衍生物越来越感兴趣。综上所述，证据表明黄酮类化合物可能是促进健康和预防疾病的膳食化合物，在现代生活方式中具有重要益处。
