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死于阿尔茨海默病型老年痴呆症患者颞叶中的四氢生物蝶呤代谢

Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type.

作者信息

Barford P A, Blair J A, Eggar C, Hamon C, Morar C, Whitburn S B

出版信息

J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):736-8. doi: 10.1136/jnnp.47.7.736.

DOI:10.1136/jnnp.47.7.736
PMID:6747650
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1027905/
Abstract

There is a defect in tetrahydrobiopterin metabolism in brains from subjects with senile dementia of Alzheimer type compared to age-matched controls. This defect results in lowered total biopterin concentrations in brain. Brains from subjects with senile dementia of Alzheimer type retain their ability to synthesis neopterin and have normal dihydropteridine reductase activity, indicating a specific loss of ability to convert dihydroneopterin triphosphate to tetrahydrobiopterin.

摘要

与年龄匹配的对照组相比，阿尔茨海默型老年痴呆症患者大脑中的四氢生物蝶呤代谢存在缺陷。这种缺陷导致大脑中生物蝶呤的总浓度降低。阿尔茨海默型老年痴呆症患者的大脑保留了合成新蝶呤的能力，并且二氢蝶啶还原酶活性正常，这表明将二氢新蝶呤三磷酸转化为四氢生物蝶呤的能力存在特定丧失。

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J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):736-8. doi: 10.1136/jnnp.47.7.736.
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本文引用的文献

1
Analysis of reduced forms of biopterin in biological tissues and fluids.生物组织和体液中生物蝶呤还原形式的分析。
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Tetrahydrobiopterin metabolism in senile dementia of Alzheimer type.阿尔茨海默病型老年痴呆中的四氢生物蝶呤代谢
J Neurol Neurosurg Psychiatry. 1983 Jun;46(6):582. doi: 10.1136/jnnp.46.6.582.
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Interactions of valproic acid with phenytoin.丙戊酸与苯妥英的相互作用。
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Tetrahydrobiopterin metabolism in senile dementia of Alzheimer type.阿尔茨海默病型老年痴呆症中的四氢生物蝶呤代谢
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