死于阿尔茨海默病型老年痴呆症患者颞叶中的四氢生物蝶呤代谢
Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type.
作者信息
Barford P A, Blair J A, Eggar C, Hamon C, Morar C, Whitburn S B
出版信息
J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):736-8. doi: 10.1136/jnnp.47.7.736.
Abstract
There is a defect in tetrahydrobiopterin metabolism in brains from subjects with senile dementia of Alzheimer type compared to age-matched controls. This defect results in lowered total biopterin concentrations in brain. Brains from subjects with senile dementia of Alzheimer type retain their ability to synthesis neopterin and have normal dihydropteridine reductase activity, indicating a specific loss of ability to convert dihydroneopterin triphosphate to tetrahydrobiopterin.
摘要
与年龄匹配的对照组相比，阿尔茨海默型老年痴呆症患者大脑中的四氢生物蝶呤代谢存在缺陷。这种缺陷导致大脑中生物蝶呤的总浓度降低。阿尔茨海默型老年痴呆症患者的大脑保留了合成新蝶呤的能力，并且二氢蝶啶还原酶活性正常，这表明将二氢新蝶呤三磷酸转化为四氢生物蝶呤的能力存在特定丧失。
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