嵌合抗原受体T细胞疗法期间的HIV核酸扩增检测假阳性
False-positive HIV nucleic acid amplification testing during CAR T-cell therapy.
作者信息
Ariza-Heredia Ella J, Granwehr Bruno P, Viola George M, Bhatti Micah, Kelley James M, Kochenderfer James, Hosing Chitra
机构信息
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX.
Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, TX.
出版信息
Diagn Microbiol Infect Dis. 2017 Aug;88(4):305-307. doi: 10.1016/j.diagmicrobio.2017.05.016. Epub 2017 Jun 3.
Abstract
Advancements in immunotherapy have opened a new era in oncology, to include genetic modification of human T-cells to express a chimeric antigen receptor (CAR) that enables targeted tumor recognition (Kochenderfer et al., 2015; Lee et al., 2015; Maus and Levine 2016; Rosenberg et al., 2008). Herein, we report a false-positive HIV testing in a patient who had undergone CAR T-cell therapy created with a lentiviral vector.
摘要
免疫疗法的进展开启了肿瘤学的新纪元，其中包括对人类T细胞进行基因改造，使其表达嵌合抗原受体（CAR），从而实现靶向肿瘤识别（Kochenderfer等人，2015年；Lee等人，2015年；Maus和Levine，2016年；Rosenberg等人，2008年）。在此，我们报告一例接受慢病毒载体构建的CAR T细胞治疗患者出现HIV检测假阳性的情况。
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