Lee Yeji, Phat Chanvorleak, Hong Soon-Cheol
College of Medicine, Korea University, Seoul, Republic of Korea.
School of Food Science and Technology, Chung-Ang University, Anseong-Si, Gyeonggi-Do, Republic of Korea.
Peptides. 2017 Sep;95:94-105. doi: 10.1016/j.peptides.2017.06.002. Epub 2017 Jun 10.
Many cyclic peptides and analogues derived from marine sources are known to possess biological properties, including anticancer, antitumor, antibacterial, antifungal, antiparasitic, anti-inflammation, anti-proliferative, anti-hypertensive, cytotoxic, and antibiotic properties. These compounds demonstrate different activities and modes of action according to their structure such as cyclic oligopeptide, cyclic lipopeptide, cyclic glycopeptide and cyclic depsipeptide. The recent advances in application of the above-mentioned cyclic peptides were reported in dolastatins, soblidotin, didemnin B, aplidine, salinosporamide A, kahalalide F and bryostatin 1 and they are currently in clinical trials. These cyclic peptides are possible novel drugs discovered and developed from marine origin. Literature data concerning the potential properties of marine cyclic peptides were reviewed here, and the structural diversity and biological activities of marine cyclic peptides are discussed in relation to the molecular mechanisms of these marine cyclic peptides.
已知许多源自海洋的环肽及其类似物具有生物活性，包括抗癌、抗肿瘤、抗菌、抗真菌、抗寄生虫、抗炎、抗增殖、抗高血压、细胞毒性和抗生素特性。这些化合物根据其结构，如环寡肽、环脂肽、环糖肽和环缩肽，表现出不同的活性和作用方式。上述环肽在多拉司他汀、soblidotin、地昔尼尔、阿利地嗪、盐孢霉素A、kahalalide F和苔藓抑素1中的应用的最新进展已有报道，它们目前正处于临床试验阶段。这些环肽是可能从海洋来源发现和开发的新型药物。本文综述了有关海洋环肽潜在特性的文献数据，并结合这些海洋环肽的分子机制讨论了海洋环肽的结构多样性和生物活性。
