Jenssen T G, Haukland H H, Vonen B, Florholmen J, Burhol P G, Maltau J M
Department of Medicine (Laboratory of Gastroenterology), University Hospital of Tromsø, Norway.
Br J Obstet Gynaecol. 1988 Jun;95(6):565-70. doi: 10.1111/j.1471-0528.1988.tb09484.x.
Intestinal transit time increases and gastrointestinal incretin effect is reported to decrease in pregnancy. The release patterns of gastrointestinal hormones related to these functions were studied in eight women before and after ingestion of a standardized meal at 32-34 weeks gestation and at 4 days postpartum. Basal plasma motilin and the integrated meal response of motilin, pancreatic polypeptide (PP) and gastric inhibitory polypeptide (GIP) were significantly lower in pregnancy than postpartum. The meal-induced rise of somatostatin and vasoactive intestinal polypeptide (VIP) was, however, absent in late pregnancy; whereas the somatostatin response recovered postpartum, and the plasma VIP concentrations stabilized at significantly higher levels postpartum without any meal response. Basal and meal-induced plasma insulin were significantly higher in pregnancy.
据报道，孕期肠道转运时间增加，胃肠肠促胰素效应降低。在8名女性妊娠32 - 34周和产后4天时，在摄入标准化餐后，研究了与这些功能相关的胃肠激素的释放模式。孕期基础血浆胃动素以及胃动素、胰多肽（PP）和胃抑制多肽（GIP）的综合餐食反应显著低于产后。然而，妊娠晚期餐后生长抑素和血管活性肠多肽（VIP）没有升高；产后生长抑素反应恢复，血浆VIP浓度在产后稳定在显著更高水平，且无任何餐食反应。孕期基础和餐后血浆胰岛素显著更高。
