De Simone C, Delia S, Di Meco L, Mastroianni C, Mastropietro C, Vullo V, Sorice F
Immunol Invest. 1985 Apr;14(2):131-44. doi: 10.3109/08820138509042007.
In some of the sera from patients with amoebiasis circulating immune complexes are present which are thought to interact with lymphoid cells, enabling them to elicit a burst of oxygen consumption in PMNs. The intensity of chemiluminescence is related to the presence of C3+ and Fc IgG+ cells in the lymphoid cell suspensions employed. The generation and release of highly reactive oxygen derivatives from PMNs impair T lymphocyte proliferative responses to the E. histolytica mitogen. The Authors suggest that one of the mechanisms by which circulating immune complexes present in the sera of patients with amoebiasis may interfere with T cell-mediated immune responses, is through their binding to the surface of the C3+, Fc IgG+ cells with subsequent stimulation of the PMN oxidative metabolism.
在一些阿米巴病患者的血清中存在循环免疫复合物，这些复合物被认为与淋巴细胞相互作用，使它们能够引发中性粒细胞的耗氧量激增。化学发光强度与所用淋巴细胞悬液中C3+和Fc IgG+细胞的存在有关。中性粒细胞产生和释放的高活性氧衍生物会损害T淋巴细胞对溶组织内阿米巴有丝分裂原的增殖反应。作者认为，阿米巴病患者血清中存在的循环免疫复合物可能干扰T细胞介导的免疫反应的机制之一，是它们与C3+、Fc IgG+细胞表面结合，随后刺激中性粒细胞的氧化代谢。
