Chu Dinh-Toi, Tao Yang, Son Le Hoang, Le Duc-Hau
Institute for Research and Development, Duy Tan University, 03 Quang Trung, Da Nang, Vietnam.
Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam.
J Physiol Biochem. 2016 Aug;73(3):315-321. doi: 10.1007/s13105-017-0567-z. Epub 2017 Jun 14.
Recent investigations have showed that the functional thermogenic adipocytes are present in both infants and adult humans. Accumulating evidence suggests that the coexistence of classical and inducible brown (brite) adipocytes in humans at adulthood and these adipocytes function to generate heat from energy resulting in reducing body fat and improving glucose metabolism. Human thermogenic adipocytes can be differentiated in vitro from stem cells, cell lines, or adipose stromal vascular fraction. Pre-activated human brite adipocytes in vitro can maintain their thermogenic function in normal or obese immunodeficient mice; therefore, they improve glucose homeostasis and reduce fat mass in obese animals. These key findings have opened a new door to use in vitro thermogenic adipocytes as a cell therapy to prevent obesity and related disorders. Thus, this paper intends to highlight our knowledge in aspects of in vitro human brite/brown adipocytes for the further studies.
最近的研究表明，功能性产热脂肪细胞在婴儿和成年人中均有存在。越来越多的证据表明，成年人体内经典型和诱导型棕色（brite）脂肪细胞共存，这些脂肪细胞的功能是利用能量产生热量，从而减少体脂并改善葡萄糖代谢。人产热脂肪细胞可在体外从干细胞、细胞系或脂肪基质血管成分中分化而来。体外预激活的人brite脂肪细胞在正常或肥胖免疫缺陷小鼠中可维持其产热功能；因此，它们可改善肥胖动物的葡萄糖稳态并减少脂肪量。这些关键发现为将体外产热脂肪细胞用作预防肥胖及相关疾病的细胞疗法打开了一扇新的大门。因此，本文旨在突出我们在体外人brite/棕色脂肪细胞方面的知识，以供进一步研究。
