Department of Neurology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 03756, USA.
Cheyenne Regional Medical Group, Cheyenne, WY, 82001, USA.
Neurotox Res. 2018 Jan;33(1):222-226. doi: 10.1007/s12640-017-9752-7. Epub 2017 Jun 13.
Neurodegenerative diseases are a major public health issue throughout the world with devastating effects on patients and families. Sporadic forms of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis are generally thought to develop as a consequence of genetic susceptibility and environmental influences. A number of environmental triggers have been identified in association with amyotrophic lateral sclerosis and Parkinson's disease. We discuss the role of β-methylamino-L-alanine in the development of neurodegeneration and the potential importance of this neurotoxin as a risk for neurodegeneration.
神经退行性疾病是全世界的一个主要公共卫生问题，对患者及其家庭造成严重影响。阿尔茨海默病、帕金森病和肌萎缩侧索硬化症等散发性神经退行性疾病通常被认为是遗传易感性和环境影响共同作用的结果。已经发现了一些与肌萎缩侧索硬化症和帕金森病相关的环境触发因素。我们讨论了β-甲基氨基-L-丙氨酸在神经退行性变发展中的作用，以及这种神经毒素作为神经退行性变风险的潜在重要性。
