Department of Emergency Medicine, Chonnam National University Medical School, Hak Dong 8, Donggu, Gwangju, 501-747, South Korea.
The Heart Center of Chonnam National University Hospital, The Research Institute of Medical Sciences, Chonnam National University, Gwangju, 501-747, South Korea.
Cardiovasc Toxicol. 2018 Feb;18(1):99-107. doi: 10.1007/s12012-017-9418-y.
This study aimed to compare adverse cardiovascular events and fatalities and to identify the risk factors for fatalities associated with the glyphosate salt herbicide formulation. Additionally, we examined whether glyphosate ammonium salt herbicides increased serum ammonia levels. One hundred forty-seven patients were divided into an ammonium group (glyphosate ammonium salt herbicide) and an isopropylamine (IPA) group (glyphosate IPA salt herbicide) according to the type of glyphosate salt formulation ingested. Although no differences in the variables were observed between the groups, the IPA group had more fatalities, a higher incidence of QTc prolongation and a higher tendency for PR prolongation than the ammonium group. Additionally, the IPA group required a longer duration of vasopressor administration. PR prolongation and age were independently associated with fatalities in glyphosate IPA salt poisoning cases in the multivariate regression. Serum ammonia levels were higher at presentation and decreased continuously during the first 48 h after presentation in the ammonium group. This study is the first to suggest potentially different toxicities, especially cardiovascular effects, of glyphosate herbicide poisoning in humans based on the glyphosate salt herbicide formulation and to determine the association between PR prolongation and fatality in glyphosate IPA salt herbicide poisoning cases.
本研究旨在比较 glyphosate 盐类除草剂制剂相关的不良心血管事件和死亡，并确定与死亡相关的危险因素。此外，我们还研究了 glyphosate 铵盐除草剂是否会增加血清氨水平。根据摄入的 glyphosate 盐制剂类型，将 147 名患者分为铵组（glyphosate ammonium salt herbicide，glyphosate 铵盐除草剂）和异丙胺（IPA）组（glyphosate IPA salt herbicide，glyphosate IPA 盐除草剂）。尽管两组之间观察到的变量没有差异，但 IPA 组的死亡率更高，QTc 延长的发生率更高，PR 延长的趋势更高。此外，IPA 组需要更长时间的血管加压药治疗。多变量回归分析显示，PR 延长和年龄与 glyphosate IPA 盐中毒病例的死亡率独立相关。铵组在入院时的血清氨水平较高，并在入院后 48 小时内持续下降。本研究首次根据 glyphosate 盐类除草剂制剂提出了 glyphosate 除草剂中毒可能具有不同的毒性，特别是心血管效应，并确定了 glyphosate IPA 盐除草剂中毒病例中 PR 延长与死亡率之间的关联。
