Chapman Benjamin P, Benedict Ralph H B, Lin Feng, Roy Shumita, Porteinsson Antoine, Szigeti Kinga, Federoff Howard, Mapstone Mark
Department of Psychiatry, University of Rochester School of Medicine and Dentistry.
Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York (SUNY), Buffalo, New York, USA.
Int J Geriatr Psychiatry. 2018 Feb;33(2):332-339. doi: 10.1002/gps.4748. Epub 2017 Jun 14.
To determine if phenotypic personality traits modify the association of Apolipoprotein E (APOE) genotypes with different domains of cognitive function.
Cross-sectional.
172 non-demented older adults were administered the NEO-Five Factor Inventory (NEO-FFI), a battery of neuropsychological tests assessing memory, attention, executive function, language, and visuospatial ability, and underwent APOE genotyping. Multivariate (multiple-dependent variable) regression models predicting cognitive domains tested APOE interactions with personality traits, adjusting for age, sex, and education.
The APOE ε4 allele showed small to modest main effects on memory and executive function (1/3 SD deficits for carriers, p < .05), with ε2 status evidencing minimal and non-significant benefit. Neuroticism interacted with both ε2 and ε4 alleles in associations with attention scores (p = .001), with ε2 benefits and ε4 deficits being marked at high Neuroticism (Mean [M] covariate-adjusted Z-score = .39 for ε2, -.47 for ε4). The association of ε4 with memory was moderated by Conscientiousness (p < .001), such that ε4 memory deficits were apparent at low Conscientiousness (M = -.56), but absent at high levels of Conscientiousness. Weaker patterns (p < .05) also suggested ε4-related detriments in executive function only at lower Conscientiousness, and ε2 memory benefits only at higher Openness.
Conscientiousness and Neuroticism moderate APOE associations with memory and executive function. As such, they may be useful phenotypic markers in refining the prognostic significance of this polymorphism. Effect-modifying personality traits also provide clues about behavioral and psychological factors that influence the cognitive impact of APOE. Copyright © 2017 John Wiley & Sons, Ltd.
确定表型人格特质是否会改变载脂蛋白E（APOE）基因与不同认知功能领域之间的关联。
横断面研究。
对172名非痴呆老年人进行了大五人格问卷简式量表（NEO-FFI）测试、一系列评估记忆、注意力、执行功能、语言和视觉空间能力的神经心理学测试，并进行了APOE基因分型。预测认知领域的多变量（多因变量）回归模型测试了APOE与人格特质的相互作用，并对年龄、性别和教育程度进行了调整。
APOE ε4等位基因对记忆和执行功能有小到中等程度的主效应（携带者有1/3标准差的缺陷，p < 0.05），而ε2状态显示出最小且不显著的益处。神经质与ε2和ε4等位基因在注意力得分方面均存在相互作用（p = 0.001），在高神经质水平时，ε2有益而ε4有缺陷（ε2的平均[M]协变量调整Z评分为0.39，ε4为-0.47）。尽责性调节了ε4与记忆的关联（p < 0.001），即ε4记忆缺陷在低尽责性水平时明显（M = -0.56），但在高尽责性水平时不存在。较弱的模式（p < 0.05）也表明，仅在较低尽责性水平时，ε4与执行功能损害有关，而ε2对记忆的益处仅在较高开放性水平时存在。
尽责性和神经质调节了APOE与记忆和执行功能的关联。因此，它们可能是用于完善这种多态性预后意义的有用表型标志物。影响效应的人格特质也为影响APOE认知作用的行为和心理因素提供了线索。版权所有© 2017约翰威立父子有限公司。
