University of Montpellier, France.
College of Medicine, Florida State University, USA.
J Psychiatr Res. 2018 Dec;107:110-113. doi: 10.1016/j.jpsychires.2018.10.015. Epub 2018 Oct 23.
Alzheimer's disease (AD) polygenic risk score (PGS) is associated with lower cognitive functioning even among older individuals without dementia. We tested the hypothesis that personality traits mediate the association between AD genetic risk and cognitive functioning. Participants (N > 7,000, aged 50-99 years old) from the Health and Retirement Study were genotyped and completed personality and cognition tests at baseline. Cognition was assessed again four years later. Bootstrap analysis revealed that a higher AD polygenic risk score was associated with lower cognitive scores at baseline through higher neuroticism, lower conscientiousness, and lower levels of the industriousness facet of conscientiousness. In addition, a higher polygenic score for AD was associated with decline in cognition over four years in part through higher neuroticism and lower conscientiousness. The findings support the hypothesis that the genetic vulnerability for AD contributes to cognitive functioning in part through its association with personality traits.
阿尔茨海默病（AD）多基因风险评分（PGS）与认知功能降低相关，即使在没有痴呆的老年人群中也是如此。我们检验了一个假设，即人格特质在 AD 遗传风险和认知功能之间起中介作用。健康与退休研究（Health and Retirement Study）的参与者（N > 7000 人，年龄在 50-99 岁之间）在基线时进行了基因分型，并完成了人格和认知测试。四年后再次评估认知。bootstrap 分析显示，AD 多基因风险评分越高，通过更高的神经质、更低的尽责性和尽责性中勤奋特质的水平，与基线时认知评分越低相关。此外，AD 的多基因评分越高，通过更高的神经质和更低的尽责性，与四年内认知下降相关。研究结果支持了这样一个假设，即 AD 的遗传易感性部分通过与人格特质的关联，导致认知功能下降。
