Asokan Shibu Marthandam, Kuo Wei-Wen, Kuo Chia-Hua, Day Cecilia-Hsuan, Shen Chia-Yao, Chung Li-Chin, Lai Chao-Hung, Pan Lung-Fa, Vijaya Padma V, Huang Chih-Yang
Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan.
Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan.
Biomedicine (Taipei). 2017 Jun;7(2):11. doi: 10.1051/bmdcn/2017070204. Epub 2017 Jun 14.
The 17 beta-estradiol (E2) is a sex hormone that is most abundant and most active estrogen in premenopausal women. The importance of E2 in providing cardioprotection and reducing the occurrence of heart disease in women of reproductive age has been well recognized. There are three subtype of estrogen receptors (ERs), including ERα, ERβ and GPR30 have been identified and accumulating evidence reveal their roles on E2-mediated genomic and nongenomic pathway in cardiomyocytes against various cardiac insults. In this review, we focus on the estrogen and ERs mediated signaling pathways in cardiomyocytes that determines cardio-protection against various stresses and further discuss the clinical implication of ERs and phytoestrogens. Further we provide some insights on phytoeostrogens which may play as alternatives in estrogen replacement therapies.
17β-雌二醇（E2）是一种性激素，在绝经前女性中是含量最丰富、活性最强的雌激素。E2在为育龄期女性提供心脏保护和降低心脏病发生率方面的重要性已得到充分认可。已鉴定出三种雌激素受体（ERs）亚型，包括ERα、ERβ和GPR30，越来越多的证据揭示了它们在心肌细胞中E2介导的基因组和非基因组途径中对各种心脏损伤的作用。在本综述中，我们聚焦于心肌细胞中雌激素和ERs介导的信号通路，这些通路决定了对各种应激的心脏保护作用，并进一步讨论ERs和植物雌激素的临床意义。此外，我们对可能在雌激素替代疗法中发挥替代作用的植物雌激素提供了一些见解。
