Helaly Soleiman E, Kuephadungphan Wilawan, Phongpaichit Souwalak, Luangsa-Ard Janet Jennifer, Rukachaisirikul Vatcharin, Stadler Marc
Department of Microbial Drugs, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.
Department of Chemistry, Faculty of Science, Aswan University, Aswan 81528, Egypt.
Molecules. 2017 Jun 14;22(6):991. doi: 10.3390/molecules22060991.
Five new compounds including the glycosylated β-naphthol (, akanthol), a glycosylated pyrazine (, akanthozine), and three amide derivatives including a hydroxamic acid derivative (-) were isolated from the spider-associated fungus (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by .
从与蜘蛛相关的真菌（麦角菌科，子囊菌门）中分离出了五种新化合物，包括糖基化的β-萘酚（棘孢酚）、一种糖基化的吡嗪（棘孢嗪）以及三种酰胺衍生物，其中一种是异羟肟酸衍生物（-）。通过高分辨率质谱（HRMS）和核磁共振光谱对它们的结构进行了阐明。在本研究中，评估了这些新化合物的抗菌、细胞毒性、抗生物膜和杀线虫活性。还揭示了该物种中次生代谢产物的分布模式，其中遇到了更多的该真菌分离株，并使用配备二极管阵列和质谱检测的分析型高效液相色谱（HPLC-DAD/MS）对其次生代谢产物谱进行了检测。值得注意的是，所有分离出的化合物都是该真菌特有的。
