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拉克纽菌素和拉克纽醇A,来自子囊菌纸质拉克纽菌(Karst.)Karst.的具有杀线虫和抗菌活性的新代谢产物。I. 产生菌、发酵、分离及生物活性

Lachnumon and lachnumol a, new metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. I. Producing organism, fermentation, isolation and biological activities.

作者信息

Stadler M, Anke H, Arendholz W R, Hansske F, Anders U, Sterner O, Bergquist K E

机构信息

Universität Kaiserslautern, Lehrbereich Biotechnologie, Fed. Rep. Germany.

出版信息

J Antibiot (Tokyo). 1993 Jun;46(6):961-7. doi: 10.7164/antibiotics.46.961.

DOI:10.7164/antibiotics.46.961
PMID:8344878
Abstract

Several chlorinated metabolites with nematicidal, antimicrobial, and cytotoxic activities were isolated from submerged cultures of the ascomycete Lachnum papyraceum. Three compounds were identified as (+)-mycorrhizin A (3), (+)-chloromycorrhizin A (4) and (+)-dechloromycorrhizin A (5). The occurrence of 5 as a natural product is new. Two compounds, lachnumon (1) and lachnumol A (2), were found to be new fungal metabolites with cytotoxic, nematicidal and antimicrobial activities.

摘要

从子囊菌纸状垂幕菇的深层培养物中分离出了几种具有杀线虫、抗菌和细胞毒性活性的氯化代谢产物。三种化合物被鉴定为(+)-菌根菌素A(3)、(+)-氯菌根菌素A(4)和(+)-脱氯菌根菌素A(5)。5作为一种天然产物的出现是新的。两种化合物,垂幕菌素(1)和垂幕醇A(2),被发现是具有细胞毒性、杀线虫和抗菌活性的新型真菌代谢产物。

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