银（I）催化二氟乙酸酯与活性烯烃进行氧化脱羧反应以形成二氟氧化吲哚。
Ag(i)-Catalyzed oxidative decarboxylation of difluoroacetates with activated alkenes to form difluorooxindoles.
作者信息
Wan Wen, Li Jialiang, Ma Guobin, Chen Yunrong, Jiang Haizhen, Deng Hongmei, Hao Jian
机构信息
Department of Chemistry, Innovative Drug Research Center, Shanghai University, China.
出版信息
Org Biomol Chem. 2017 Jun 27;15(25):5308-5317. doi: 10.1039/c7ob00955k.
PMID:28613344
Abstract
A silver-catalyzed oxidative decarboxylative gem-difluoromethylenation of difluoroacetates with activated alkenes under mild reaction conditions has been developed. This radical cascade reaction provides a new method for the construction of a variety of gem-difluoromethylenated oxindoles.
摘要
已开发出一种在温和反应条件下，银催化二氟乙酸酯与活性烯烃的氧化脱羧偕二氟亚甲基化反应。这种自由基串联反应为构建多种偕二氟亚甲基化的氧化吲哚提供了一种新方法。
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