温和条件下二氟芳甲基取代的苯并咪唑并[2,1-]异喹啉-6(5)-酮的合成
Synthesis of Difluoroarymethyl-Substituted Benzimidazo[2,1-]isoquinolin-6(5)-ones under Mild Conditions.
作者信息
Sui Kaixia, Leng Yuting, Wu Yangjie
机构信息
Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450052, P. R. China.
出版信息
ACS Omega. 2023 Feb 14;8(8):7517-7528. doi: 10.1021/acsomega.2c06689. eCollection 2023 Feb 28.
A highly efficient method for synthesis of difluoroarymethyl-substituted benzimidazo[2,1-]isoquinolin-6(5)-ones using 2-arylbenzoimidazoles with α,α-difluorophenylacetic acid as reaction substrates has been developed through radical cascade cyclization. The advantage of this strategy lies in excellent functional group tolerance to generate the corresponding products in good yields under base- and metal-free conditions.
通过自由基级联环化反应，开发了一种以2-芳基苯并咪唑和α,α-二氟苯乙酸为反应底物，高效合成二氟芳甲基取代的苯并咪唑并[2,1-]异喹啉-6(5)-酮的方法。该策略的优点在于对官能团具有优异的耐受性，能够在无碱和无金属条件下以良好的产率生成相应的产物。
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