Karti Omer, Nalbantoglu Ozlem, Abali Saygin, Ayhan Ziya, Tunc Selma, Kusbeci Tuncay, Ozkan Behzat
Ophthalmic Surg Lasers Imaging Retina. 2017 Jun 1;48(6):473-477. doi: 10.3928/23258160-20170601-05.
Early diabetic retinal changes in children with type 1 diabetes mellitus (T1DM) without diabetic retinopathy (DR) were examined using spectral-domain optical coherence tomography (SD-OCT).
Sixty children with T1DM without DR and 60 normal children were enrolled in the study. SD-OCT was used to measure the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber (RNFL) thicknesses in all participants.
The GC-IPL thickness was significantly decreased in all quadrants except the superior-nasal quadrant in children with diabetes (P < .05). However, the RNFL thickness in all quadrants was not significantly different between the groups (P > .05).
There was a decreased GC-IPL thickness in children with T1DM without DR, suggesting that T1DM has an early neurodegenerative effect on retinal ganglion cells that occurs when the vascular component of DR is absent. SD-OCT may be more useful than ophthalmoscopic evaluation for detecting the earlier retinal structural changes of diabetes. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:473-477.].
使用频域光学相干断层扫描（SD - OCT）检查1型糖尿病（T1DM）且无糖尿病视网膜病变（DR）患儿的早期糖尿病视网膜改变。
本研究纳入了60例无DR的T1DM患儿和60例正常儿童。使用SD - OCT测量所有参与者的神经节细胞 - 内丛状层（GC - IPL）和视网膜神经纤维层（RNFL）厚度。
糖尿病患儿除鼻上象限外，所有象限的GC - IPL厚度均显著降低（P < 0.05）。然而，两组之间所有象限的RNFL厚度无显著差异（P > 0.05）。
无DR的T1DM患儿GC - IPL厚度降低，提示T1DM在无DR血管病变时就对视网膜神经节细胞有早期神经退行性影响。对于检测糖尿病早期视网膜结构改变，SD - OCT可能比检眼镜检查更有用。[《眼科手术、激光与视网膜成像》。2017；48：473 - 477。]
