Asik Abdulvahit, Bolu Semih, Direkci Ilke, Aydemir Emre, Aydemir Gozde Aksoy
Department of Pediatrics, Adıyaman University Education and Research Hospital, Adıyaman, Turkey.
Department of Pediatric Endocrinology, Adıyaman University Education and Research Hospital, Adıyaman, Turkey.
Ther Adv Ophthalmol. 2022 Jul 7;14:25158414221101710. doi: 10.1177/25158414221101710. eCollection 2022 Jan-Dec.
It is important to determine changes in posterior ocular structures in the early period before retinopathy develops in pediatric patients with type 1 diabetes mellitus (DM).
To evaluate inner plexiform layer (IPL), ganglion cell layer (GCL), and retinal nerve fiber layer (RNFL) thicknesses, as well as the relationship between choroidal thickness (CT) and ocular pulse amplitude (OPA) in type 1 diabetic children without diabetic retinopathy (DR).
A prospective observational study.
Group 1 ( = 44) consisted of pediatric patients with type 1 DM without DR, and Group 2 ( = 65) of pediatric control subjects. Both intraocular pressure (IOP) and OPA were measured using a dynamic contour tonometer. CT, IPL, GCL, and RNFL were all measured using spectral domain optical coherence tomography (OCT).
The mean IOP and OPA values were 16.67 ± 2.34 and 1.85 ± 0.34, respectively, in group 1, and 15.14 ± 2.17 and 1.65 ± 0.25 in Group 2 ( = 0.001 for both). The mean subfoveal CT value was 294.30 ± 67.61 μm in group 1 and 394.42 ± 69.65 μm in Group 2 ( < 0.001). The mean GCL and RNFL values were 1.09 ± 0.11 and 96.46 ± 11.69, respectively, in group 1, and 1.14 ± 0.09 and 101.73 ± 9.33 in Group 2 ( = 0.005 and = 0.008, respectively).
IOP and OPA values were higher, and CT, GCL, and RNFL values were lower in children with type 1 DM during the early stages than in the healthy control group. These findings suggest that CT may be a marker of retinal involvement in children with type 1 DM without DR.
在1型糖尿病（DM）患儿视网膜病变发生前的早期阶段，确定眼后段结构的变化非常重要。
评估1型糖尿病且无糖尿病视网膜病变（DR）患儿的内网状层（IPL）、神经节细胞层（GCL）和视网膜神经纤维层（RNFL）厚度，以及脉络膜厚度（CT）与眼脉搏振幅（OPA）之间的关系。
一项前瞻性观察研究。
第1组（n = 44）由1型DM且无DR的患儿组成，第2组（n = 65）为儿科对照受试者。使用动态轮廓眼压计测量眼压（IOP）和OPA。使用光谱域光学相干断层扫描（OCT）测量CT、IPL、GCL和RNFL。
第1组的平均IOP和OPA值分别为16.67±2.34和1.85±0.34，第2组为15.14±2.17和1.65±0.25（两者P均 = 0.001）。第1组的平均黄斑下CT值为294.30±67.61μm，第2组为394.42±69.65μm（P < 0.001）。第1组的平均GCL和RNFL值分别为1.09±0.11和96.46±11.69，第2组为1.14±0.09和101.73±9.33（P分别 = 0.005和P = 0.008）。
1型DM患儿早期的IOP和OPA值较高，而CT、GCL和RNFL值低于健康对照组。这些发现表明，CT可能是1型DM且无DR患儿视网膜受累的一个标志物。
