Akhouri Shweta, Kuhn James, Newton Edward J.
University of Louisville
Aventura Hospital and Medical Center
Wernicke-Korsakoff syndrome is a common complication of a thiamine deficiency that is primarily seen with alcoholics. This syndrome was classically described as a clinical triad consisting of altered mental status (i.e., confusion or dementia), nystagmus (or ophthalmoplegia), and ataxia. However, fewer than one-third of patients present with this complete triad. Wernicke-Korsakoff syndrome is a term that encompasses two different syndromes, Wernicke encephalopathy and Korsakoff syndrome. Wernicke encephalopathy is characterized by an acute confusional state with clinical features that are often reversible. Korsakoff syndrome is characterized by confabulation, memory loss, and gait abnormalities that are often irreversible and result from Wernicke encephalopathy if not treated adequately.
韦尼克-科尔萨科夫综合征是硫胺素缺乏的常见并发症，主要见于酗酒者。该综合征传统上被描述为一个临床三联征，包括精神状态改变（即意识模糊或痴呆）、眼球震颤（或眼肌麻痹）和共济失调。然而，不到三分之一的患者会出现这一完整的三联征。韦尼克-科尔萨科夫综合征是一个涵盖两种不同综合征的术语，即韦尼克脑病和科尔萨科夫综合征。韦尼克脑病的特征是急性意识模糊状态，其临床特征通常是可逆的。而科尔萨科夫综合征的特征是虚构、记忆丧失和步态异常，这些通常是不可逆的，如果韦尼克脑病没有得到充分治疗就会出现。
