Liu Song, Wang Meng, Wang Gefei, Wu Xiuwen, Guan Wenxian, Ren Jianan
1 Department of General Surgery, Nanjing Drum Tower Hospital , he Affiliated Hospital of Nanjing University Medical School, Nanjing, China .
2 Department of General Surgery, Jinling Hospital, School of Medicine, Nanjing University , Nanjing, China .
Surg Infect (Larchmt). 2017 Aug/Sep;18(6):676-683. doi: 10.1089/sur.2017.037. Epub 2017 Jun 14.
Nosocomial infections are the main adverse events during health care delivery. Hand hygiene is the fundamental strategy for the prevention of nosocomial infections. Microbial characteristics of nosocomial infections in the Asia-Pacific region have not been investigated fully. Correlation between the use of hand hygiene products and the incidence of nosocomial infections is still unknown. This study investigates the microbial characteristics of nosocomial infections in the Asia-Pacific region and analyzes the association between the utilization of hand hygiene products and the incidence of nosocomial infections.
A total of 78,344 patients were recruited from a major tertiary hospital in China. Microbial characteristics of major types of nosocomial infections were described. The association between the utilization of hand hygiene products and the incidence of nosocomial infections was analyzed using correlation and regression models.
The overall incidence of nosocomial infections was 3.04%, in which the incidence of surgical site infection was 1%. Multi-drug resistance was found in 22.8% of all pathogens, in which multi-drug-resistant Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus were 56.6% and 54.9%, respectively. The utilization of hand hygiene products (including hand sanitizer, soap and paper towel) was associated negatively with the incidence of surgical site infection in surgical departments and the incidence of nosocomial infections in non-intensive care unit (ICU) departments (especially in surgical departments). Regression analysis further identified that higher utilization of hand hygiene products correlated with decreased incidence of major types of nosocomial infections.
Multi-drug-resistant organisms are emerging in Asia-Pacific health care facilities. Utilization of hand hygiene products is associated with the incidence of nosocomial infections.
医院感染是医疗服务过程中的主要不良事件。手卫生是预防医院感染的基本策略。亚太地区医院感染的微生物特征尚未得到充分研究。手卫生产品的使用与医院感染发生率之间的相关性仍不清楚。本研究调查亚太地区医院感染的微生物特征，并分析手卫生产品的使用与医院感染发生率之间的关联。
从中国一家大型三级医院招募了总共78344名患者。描述了主要类型医院感染的微生物特征。使用相关性和回归模型分析了手卫生产品的使用与医院感染发生率之间的关联。
医院感染的总体发生率为3.04%，其中手术部位感染的发生率为1%。在所有病原体中，22.8%发现有多重耐药性，其中多重耐药鲍曼不动杆菌和耐甲氧西林金黄色葡萄球菌分别占56.6%和54.9%。手卫生产品（包括洗手液、肥皂和纸巾）的使用与外科手术科室的手术部位感染发生率以及非重症监护病房（ICU）科室（尤其是外科手术科室）的医院感染发生率呈负相关。回归分析进一步确定，手卫生产品的较高使用与主要类型医院感染的发生率降低相关。
多重耐药菌正在亚太地区的医疗机构中出现。手卫生产品的使用与医院感染的发生率相关。
