Departments of *Medicine, Division of Rheumatology †Oncology ‡Otolaryngology §Radiology, Johns Hopkins School of Medicine, Baltimore, MD.
J Immunother. 2017 Oct;40(8):312-314. doi: 10.1097/CJI.0000000000000174.
We report the acute onset of aseptic sinusitis in 2 patients receiving the immune checkpoint inhibitors, ipilimumab and nivolumab, for treatment of metastatic melanoma. Ipilimumab, a monoclonal antibody targeting cytotoxic T-lymphocyte antigen-4, and nivolumab, targeting programmed cell death-1, have been associated with numerous immune-related adverse events. To the authors' knowledge, this is the first report of aseptic sinusitis as a consequence of immune checkpoint inhibition therapy.
我们报告了 2 例接受免疫检查点抑制剂伊匹单抗和纳武单抗治疗转移性黑色素瘤的患者发生急性无菌性鼻窦炎。伊匹单抗是一种针对细胞毒性 T 淋巴细胞抗原-4 的单克隆抗体，纳武单抗是一种针对程序性死亡受体-1 的单克隆抗体，它们与许多免疫相关的不良反应有关。据作者所知，这是首例免疫检查点抑制治疗导致无菌性鼻窦炎的报告。
