Vaughn Alexandra R, Sivamani Raja K, Lio Peter A, Shi Vivian Y
From the *Drexel University College of Medicine, Philadelphia, PA; †Department of Dermatology, University of California, Davis; ‡Department of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL; and §Department of Medicine, Dermatology Division, University of Arizona, Tucson.
Dermatitis. 2017 Jul-Aug;28(4):241-245. doi: 10.1097/DER.0000000000000305.
Atopic dermatitis (AD) is a common inflammatory skin disease that chronically affects children and adults worldwide. Environmental exposures, heritable factors, immune dysregulation, and skin barrier malfunction all contribute to the multifactorial nature of AD. It is known that maternal and paternal influences are important predictors for the risk of AD in offspring. This review examines and compares the evidence and mechanisms behind specific maternal and paternal factors that may contribute to the pathogenesis of AD.
特应性皮炎（AD）是一种常见的炎症性皮肤病，在全球范围内长期影响儿童和成人。环境暴露、遗传因素、免疫失调和皮肤屏障功能障碍都导致了AD的多因素性质。已知母体和父体影响是后代患AD风险的重要预测因素。本综述研究并比较了可能导致AD发病机制的特定母体和父体因素背后的证据和机制。
