Vaughn Alexandra R, Tannhauser Paige, Sivamani Raja K, Shi Vivian Y
College of Medicine, Drexel University, Philadelphia, Pennsylvania.
Department of Dermatology, University of California at Davis, Sacramento, California.
Pediatr Dermatol. 2017 May;34(3):240-246. doi: 10.1111/pde.13149.
Atopic dermatitis (AD) is a highly prevalent chronic inflammatory skin disease. Current knowledge about the etiology of AD suggests that it is multifactorial and involves the interaction of several factors, including environmental triggers, genetics, immunologic factors, and skin barrier dysfunction. The prenatal environment has a significant influence on fetal development, including the maturation of skin barrier function. This review summarizes maternal factors that have been reported to influence the development of AD in offspring, including maternal genetics, nutrition, breastfeeding, environment, and behaviors.
特应性皮炎（AD）是一种高度常见的慢性炎症性皮肤病。目前关于AD病因的认识表明，其病因是多因素的，涉及多种因素的相互作用，包括环境触发因素、遗传学、免疫因素和皮肤屏障功能障碍。产前环境对胎儿发育有重大影响，包括皮肤屏障功能的成熟。本综述总结了据报道会影响后代AD发病的母体因素，包括母体遗传学、营养、母乳喂养、环境和行为。
