Ye Y, Dou L M, Wang L H
Department of Dermatology, Children's Hospital of Fudan University, Shanghai 201102, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2023 Sep 6;57(9):1489-1496. doi: 10.3760/cma.j.cn112150-20220930-00946.
Atopic dermatitis(AD)is a chronic, recurrent, inflammatory skin disease in children. The disease is characterized by dryness, chronic eczema-like lesions and obvious itching, seriously affecting the quality of life of children and their families. The pathogenesis of AD is not yet to be clear, and it might be the interaction of genetic susceptibility and environmental exposure to induce skin barrier impairment and immune system dysfunction. In recent years, the role of maternal factors or intrauterine environment exposure on childhood allergic diseases has been attracted attention, and the hypothesis that allergic diseases originate from the fetal period has been postulated. Maternal exposures called "early life exposure", such as nutritional factors during pregnancy (folate, vitamin D, vitamin E and polyunsaturated fatty acid) and tobacco exposure, home environmental exposure may be related with childhood atopic dermatitis. This article would focus on the recent research about maternal nutritional factors and family environmental exposure during pregnancy on offspring's atopic dermatitis.
特应性皮炎（AD）是一种儿童慢性复发性炎症性皮肤病。该疾病的特征为皮肤干燥、慢性湿疹样皮损及明显瘙痒，严重影响儿童及其家庭的生活质量。AD的发病机制尚不清楚，可能是遗传易感性与环境暴露相互作用导致皮肤屏障受损和免疫系统功能障碍。近年来，母体因素或宫内环境暴露对儿童过敏性疾病的影响受到关注，有假说认为过敏性疾病始于胎儿期。孕期母体暴露，即所谓的“早期生活暴露”，如孕期营养因素（叶酸、维生素D、维生素E和多不饱和脂肪酸）及烟草暴露、家庭环境暴露等，可能与儿童特应性皮炎有关。本文将聚焦于孕期母体营养因素及家庭环境暴露对后代特应性皮炎影响的最新研究。
