可乐定可促进生长激素分泌受损儿童的生长。
Clonidine accelerates growth in children with impaired growth hormone secretion.
作者信息
Pintor C, Cella S G, Corda R, Locatelli V, Puggioni R, Loche S, Müller E E
出版信息
Lancet. 1985 Jun 29;1(8444):1482-5. doi: 10.1016/s0140-6736(85)92256-1.
PMID:2861413
Abstract
4 children with isolated growth hormone deficiency (IGHD) and 4 with constitutional growth delay (CGD) were treated with clonidine, 0.1 mg/m2 daily, for 60 days. In 2 children with IGHD and all 4 with CGD, basal growth hormone (GH) and somatomedin-C levels were increased, pituitary GH response to challenges with a synthetic pancreatic GH releasing factor and clonidine was enhanced, and linear growth was stimulated.
摘要
4名孤立性生长激素缺乏症（IGHD）患儿和4名体质性生长发育延迟（CGD）患儿接受可乐定治疗，剂量为每日0.1mg/m²，持续60天。在2名IGHD患儿和所有4名CGD患儿中，基础生长激素（GH）和胰岛素样生长因子C水平升高，垂体GH对合成胰源性GH释放因子和可乐定激发试验的反应增强，并且线性生长受到刺激。
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