Pintor C, Puggioni R, Fanni V, Cella S G, Villa A, Locatelli V, Müller E E
J Endocrinol Invest. 1984 Jun;7(3):253-6. doi: 10.1007/BF03348434.
Six male prepubertal children with constitutional growth delay (CGD), and a subnormal growth hormone (GH) response to insulin hypoglycemia, and four normal prepubertal children were given in different occasions 1 microgram/Kg iv synthetic hpGRF-40 or a single oral dose of 0.15 mg/m2 clonidine (Clon), an effective growth hormone (GH) secretagogue. In the normal children brisk and clear-cut GH rises were detected in plasma after hpGRF-40 (peak GH levels at 15-30 min) or clonidine (peak GH levels 60-90 min). In CGD children hpGRF-40 induced a biphasic response, e.g. a slight increase in plasma GH at 15 min followed by a delayed and erratic GH rise occurring 45-120 min post-injection. Also the GH response to Clon was sluggish and delayed and peak plasma GH levels were attained only 90-180 min post-drug administration. These data indicate that the CGD children of our study have a defect in the pituitary GH reserve.
六名患有体质性生长延迟（CGD）且对胰岛素低血糖的生长激素（GH）反应低于正常水平的青春期前男性儿童，以及四名正常的青春期前儿童，在不同时间分别静脉注射1微克/千克的合成hpGRF - 40或单次口服0.15毫克/平方米的可乐定（Clon），可乐定是一种有效的生长激素（GH）促分泌剂。在正常儿童中，注射hpGRF - 40后（15 - 30分钟时GH水平达到峰值）或可乐定后（60 - 90分钟时GH水平达到峰值），血浆中可检测到快速且明显的GH升高。在CGD儿童中，hpGRF - 40诱导出双相反应，例如在15分钟时血浆GH略有升高，随后在注射后45 - 120分钟出现延迟且不稳定的GH升高。对可乐定的GH反应也迟缓且延迟，仅在给药后90 - 180分钟达到血浆GH峰值水平。这些数据表明，我们研究中的CGD儿童存在垂体GH储备缺陷。
