趋化因子CXC配体12基因多态性（rs1746048）与冠心病之间的关联：一项符合MOOSE标准的荟萃分析。

Association between chemokine CXC ligand 12 gene polymorphism (rs1746048) and coronary heart disease: A MOOSE-compliant meta-analysis.

作者信息

Chen Min, Jiang Yu-Feng, Zhang Nan-Nan, Yang Hua-Jia, Xu Lang-Biao, Rui Qing, Sun Si-Jia, Yao Jia-Lu, Zhou Ya-Feng

机构信息

Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou Department of Cardiology, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, PR China.

出版信息

Medicine (Baltimore). 2017 Jun;96(24):e7179. doi: 10.1097/MD.0000000000007179.

DOI:10.1097/MD.0000000000007179

PMID:28614256

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5478341/

Abstract

Recently a large number of investigations have implicated the association between the chemokine CXC ligand 12 gene polymorphism (rs1746048) and risk of coronary heart disease (CHD), but the results remain debatable. The aim of our study was to provide more compelling evidence for the relationship between rs1746048 and CHD risk. Studies eligible for this meta-analysis were identified through electronic search of PubMed, EMBASE, and CNKI. Two authors performed independent literature review and study quality assessment by using the Newcastle-Ottawa Scale checklist. The odds ratios (ORs) with 95% confidence intervals (CIs) were pooled in a specific genetic model to assess the association. The meta-analysis of 48,852 patients and 64,386 controls from 12 studies showed that patients with rs1746048 had 1.11 times of high risk in developing CHD (OR = 1.11; 95% CI = 1.09-1.14; P < .005; I = 35.8%). The increased risk of CHD was also found in both Asian (OR = 1.07; 95%CI = 1.02-1.12; P < .005; I = 40.6%) and Caucasian populations (OR = 1.14; 95% CI = 1.10-1.18; P < .005; I = 22.2%). The results of our meta-analysis suggested that chemokine CXC ligand 12 gene polymorphism (rs1746048) may be linked with susceptibility to CHD.

摘要

最近，大量研究表明趋化因子CXC配体12基因多态性（rs1746048）与冠心病（CHD）风险之间存在关联，但结果仍存在争议。我们研究的目的是为rs1746048与冠心病风险之间的关系提供更有说服力的证据。通过电子检索PubMed、EMBASE和中国知网（CNKI）确定了符合本荟萃分析的研究。两名作者使用纽卡斯尔-渥太华量表清单进行独立的文献综述和研究质量评估。在特定遗传模型中汇总具有95%置信区间（CI）的比值比（OR）以评估关联。对12项研究中48,852例患者和64,386例对照进行的荟萃分析表明，携带rs1746048的患者患冠心病的风险高1.11倍（OR = 1.11；95%CI = 1.09 - 1.14；P <.005；I = 35.8%）。在亚洲人群（OR = 1.07；95%CI = 1.02 - 1.12；P <.005；I = 40.6%）和白种人群（OR = 1.14；95%CI = 1.10 - 1.18；P <.005；I = 22.2%）中也发现了冠心病风险增加。我们的荟萃分析结果表明，趋化因子CXC配体12基因多态性（rs1746048）可能与冠心病易感性有关。